SPIRAL CT FOR COCHLEAR IMPLANTATION

描述：(根据申请者摘要) 多电极、人工髓内植入术是治疗多发性硬化症的有效方法 耳聋，但结果因人而异。之前和之后- 手术螺旋CT可以提供耳蜗形态的三维地图和 电极阵列在耳蜗中的位置，取决于分辨率 限制。3D电极相对于耳蜗的位置知识 解剖学为建模和研究提供了基础 电刺激参数，以优化语音识别。 迫切需要从几何角度对 活体单个耳蜗骨的精确解剖定位 植入电极。这个几何模型是一个前提条件 植入性耳蜗电解剖模型的发展，并可能 帮助解释部分受试者间语音识别的可变性。 电极阵列与耳蜗腔内的几何关系 特征为干预措施的合理设计提供了基础， 设备以及它们的编程。 长期目标是定义植入的人工耳蜗的形态和 使用此3D几何信息改进语音识别。这个 具体目标是(1)通过后处理在3D中定位植入电极。 操作式X射线立体摄影测量，并结合这一信息 在相应的螺旋CT图像中；(2)耳蜗线的去模糊和解包 术前、术后螺旋CT容积图像；(3)建立和 验证单个植入的耳蜗的几何模型，以及 在患者研究中展示它们的临床可行性和实用性。 验证将使用图像分辨率模体、样本 植入了各种类型的人工耳蜗体的人类耳蜗体， 以及身体头部，其中嵌入了这些幻影和标本。 验证的黄金标准将由独立的 使用反射显微镜和显微CT获得的测量结果 幻影和标本。 完成后，植入的人工耳蜗的形态将在 基于X射线合成个性化三维几何模型的vivo 立体摄影测量和螺旋CT。X射线成像与图像分析 植入前后的诊断和研究方法 应用程序将得到验证，并应用于患者研究。一张网- 基于螺旋CT的人工耳蜗术资源库将推广 图像和建模技术以及软件。

DESCRIPTION: (as per applicant abstract) Multi-electrode, intracochlear implants are effective treatment of deafness, but the results vary between individuals. Pre- and post- operative spiral CT can provide 3D maps of cochlear morphology and electrode array position in the cochlea, subject to resolution limitations. Knowledge of 3D electrode locations relative to cochlear anatomy provides the foundation for modeling and investigation of electrical stimulation parameters to optimize speech recognition. There is a critical and immediate need to geometrically model the individual cochlea in vivo with precise anatomic localization of implanted electrodes. This geometric model is a prerequisite for development of electroanatomic models of the implanted cochlea, and may help explain part of intersubject speech recognition variability. Geometric relations between an electrode array and intracochlear features provide the basis for rational design of interventions, devices, and their programming. The long term objective is to define implanted cochlear morphology and improve speech recognition using this 3D geometric information. The specific aims are to (1) localize implant electrodes in 3D with post- operative X-ray sterophotogrammetry, and incorporate this information in corresponding spiral CT images; (2) deblur and unwrap the cochlea in volumetric spiral CT images pre- and post-operatively; (3) develop and validate geometric models of individual implanted cochleas, and demonstrate their clinical feasibility and utility in patient studies. Validation will be done with immage resolution phantoms, specimens of the human cochleas implanted with various types of cochlear implants, and cadaver heads in which these phantoms and specimens are embedded. The gold standard for validation will be established by independent measurements obtained using Reflex microscopy and micro CT of these phantoms and specimens. On completion, implanted cochlear morphology will be characterized in vivo by synthesizing individualized 3D geometric models based on X-ray stereophotogrammetry and spiral CT. X-ray imaging and image analysis methods for pre- and post-implantation diagnostic and research applications will be validated, and applied in patient studies. A Web- based resource of spiral CT for cochlear implantation will disseminate the image and modeling techniques and software.