DIAGNOSTIC OPITCAL IMAGING OF PERIODONTAL TISSUES

描述(改编自申请人摘要)：光学相干性 层析成像(OCT)是一种非侵入性的断层扫描光学技术 生物组织的成像，允许识别内部的 非电离硬、软组织的结构和表面轮廓 辐射。基于之前的赞助工作，作者设计了 构建了用于牙齿和牙周组织成像的OCT成像仪。 初步的人体研究证明了这种方法的可行性。目标是 这项提议的目的是建造一种小型、紧凑的临床仪器， 将允许进入口腔内的所有牙齿承载区域。这个 OCT表征形态、定位结构和量化的能力 牙龈下结石将在一项小型患者研究中确定。这个 作者希望识别与牙周炎和/或牙周炎相关的OCT信号 牙周炎。为了使该设备具有临床应用价值，作者 建议优化仪器并评估其在#年的性能 与标准技术进行比较。这项建议的具体目的是 (1)构建一种改进的、小型化的口腔内OCT成像手机； (2)OCT成像系统组件的小型化；(3)OCT成像与表征 健康和患病的牙周组织，优化OCT成像参数； (4)将OCT成像与标准评估方法进行比较；以及(5)调查 OCT对牙周炎进行量化的可能性。制作的图像以 数据显示OCT可显示牙龈纤维的病理改变 根据光学特性的变化进行分组。最终运行10月 多个波长的系统可用于血液和 组织中的液体含量。该项目是与 劳伦斯·利弗莫尔国家实验室。

DESCRIPTION (Adapted from Applicant's Abstract): Optical Coherence Tomography (OCT) is a non-invasive optical technique for cross-sectional imaging of biologic tissues which permits identification of both internal structure and surface contour of hard and soft tissues without ionizing radiation. Based on previously sponsored efforts, the authors have designed and constructed an OCT instrument for imaging teeth and periodontal tissues. Initial human studies demonstrate the feasibility of this method. The goal of this proposal is to construct a small, compact clinical instrument that will allow access to all tooth-bearing regions within the oral cavity. The capacity of OCT to characterize morphology, localize structures and quantify sub-gingival calculus will be determined in a small patient study. The authors hope to identify OCT signals associated with periodontitis and/or gingivitis. In order to make the device clinically relevant., the authors propose to optimize the instrument and evaluate its performance in comparison to standard techniques. The specific aims of the proposal are to (1) construct an improved, miniaturized intraoral OCT imaging hand piece; (2) miniaturize OCT imaging system components; (3) image and characterize healthy and diseased periodontal tissue and optimize OCT imaging parameters; (4) compare OCT imaging to standard assessment methods; and (5) investigate the potential of OCT to quantify gingival inflammation. Images produced to date suggest that OCT may delineate pathological changes in gingival fiber groups based on changes in optical properties. Finally operating OCT systems at multiple wavelengths may be used for quantification of blood and fluid content in tissue. This project is carried out in conjunction with Lawrence Livermore National Laboratory.