DIAGNOSTIC OPITCAL IMAGING OF PERIODONTAL TISSUES

描述（改编自申请人的摘要）： 断层扫描（OCT）是一种非侵入性的光学技术，用于横截面 生物组织的成像，其允许识别内部 硬组织和软组织的结构和表面轮廓 辐射 基于以前赞助的努力，作者设计了 并构建了用于对牙齿和牙周组织进行成像的OCT仪器。 最初的人体研究证明了这种方法的可行性。 目标 本发明的目的是构造一种小型紧凑的临床仪器， 将允许进入口腔内的所有牙齿支承区域。 的 OCT表征形态、定位结构和量化的能力 龈下牙石将在一项小型患者研究中确定。 的 作者希望识别与牙周炎和/或牙周炎相关的OCT信号， 牙龈炎 为了使器械具有临床相关性，作者 建议优化仪器并评估其性能， 与标准技术相比。 该提案的具体目标是 (1)构造改进的小型化口内OCT成像手持件; (2)对OCT成像系统组件进行测试;（3）成像和表征 并优化OCT成像参数; (4)将OCT成像与标准评估方法进行比较;以及（5）研究 OCT量化牙龈炎症的潜力。 图像制作 结果表明，OCT可以描述牙龈纤维的病理变化 根据光学性质的变化进行分组。 最后操作OCT 多个波长的系统可用于血液的定量 组织中的液体含量。 该项目是与下列项目一起进行的： 劳伦斯利弗莫尔国家实验室。

DESCRIPTION (Adapted from Applicant's Abstract): Optical Coherence Tomography (OCT) is a non-invasive optical technique for cross-sectional imaging of biologic tissues which permits identification of both internal structure and surface contour of hard and soft tissues without ionizing radiation. Based on previously sponsored efforts, the authors have designed and constructed an OCT instrument for imaging teeth and periodontal tissues. Initial human studies demonstrate the feasibility of this method. The goal of this proposal is to construct a small, compact clinical instrument that will allow access to all tooth-bearing regions within the oral cavity. The capacity of OCT to characterize morphology, localize structures and quantify sub-gingival calculus will be determined in a small patient study. The authors hope to identify OCT signals associated with periodontitis and/or gingivitis. In order to make the device clinically relevant., the authors propose to optimize the instrument and evaluate its performance in comparison to standard techniques. The specific aims of the proposal are to (1) construct an improved, miniaturized intraoral OCT imaging hand piece; (2) miniaturize OCT imaging system components; (3) image and characterize healthy and diseased periodontal tissue and optimize OCT imaging parameters; (4) compare OCT imaging to standard assessment methods; and (5) investigate the potential of OCT to quantify gingival inflammation. Images produced to date suggest that OCT may delineate pathological changes in gingival fiber groups based on changes in optical properties. Finally operating OCT systems at multiple wavelengths may be used for quantification of blood and fluid content in tissue. This project is carried out in conjunction with Lawrence Livermore National Laboratory.