Understanding and modelling reservoirs, vehicles and transmission of ESBL-producing Enterobacteriaceae in the community and long term care facilities

了解社区和长期护理机构中产 ESBL 肠杆菌科细菌的储存库、载体和传播并对其进行建模

• 批准号: MR/R004536/1
• 负责人: Ben Cooper
• 金额: $ 38.73万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR004536%2F1
• 关键词: Understanding; modelling; reservoirs; vehicles; transmission

The continuing spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) is among the most important problems in antimicrobial resistance. It is also a good model to investigate the epidemiological complexity of resistance in Enterobacteriaceae. Available data on the transmission determinants of ESBL-PE in community settings are scarce, methodologically limited and mostly based on single centre studies. A comprehensive investigation using modern typing and modelling techniques is warranted to develop a sound quantitative understanding of the interactions involved. A consortium of investigators with diverse expertise from countries with high and low endemicity of ESBL-EP has been created. Transmission and persistence of ESBL-PE within households and long-term care facilities will be studied. Individual and group-level determinants for transmission and persistence will be quantified, together with other ecological variables including environmental, food and wastewater contamination. Advanced molecular typing techniques and state-of-the-art analytical methods will be used. Data generated in this project will directly inform a suite of mathematical models which, in addition to encapsulating current understanding of the processes, will be used to explore the potential effectiveness of different interventions to control ESBL-PE spread. The expected outputs are a comprehensive characterisation of ESBL-PE transmission considering bacterial clones and mobile genetic elements, as well as individual and ecologic-level factors in different settings, to inform public health authorities about interventions that should be prioritised to control transmission of these organisms.

产超广谱β-内酰胺酶肠杆菌科（ESBL-PE）的持续传播是抗生素耐药性中最重要的问题之一。这也是研究肠杆菌科细菌耐药流行病学复杂性的一个很好的模型。关于社区环境中ESBL-PE传播决定因素的现有数据很少，方法有限，大多基于单中心研究。一个全面的调查，使用现代类型和建模技术是必要的，以发展一个健全的定量了解所涉及的相互作用。已经建立了一个由来自ESBL-EP高流行和低流行国家的具有不同专业知识的研究者组成的联盟。将研究家庭和长期护理机构内ESBL-PE的传播和持续性。将对传播和持久性的个人和群体决定因素以及环境、食品和废水污染等其他生态变量进行量化。将使用先进的分子分型技术和最先进的分析方法。该项目中生成的数据将直接为一套数学模型提供信息，这些模型除了封装当前对过程的理解外，还将用于探索不同干预措施控制ESBL-PE传播的潜在有效性。预期输出是考虑细菌克隆和移动的遗传元件以及不同环境中的个体和生态水平因素的ESBL-PE传播的综合表征，以告知公共卫生当局应优先采取的干预措施，以控制这些生物体的传播。

项目成果

Dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting

碳青霉烯类耐药质粒 pOXA-48 在医院环境中的传播途径

• DOI: 10.1101/2020.04.20.050476
• 发表时间: 2020
• 作者: León-Sampedro R

Acquisition and carriage dynamics of fluoroquinolone resistant Enterobacteriaceae at individual and household levels

个人和家庭层面耐氟喹诺酮类肠杆菌科细菌的获取和携带动态

• DOI: 10.1101/2020.10.29.20222364
• 发表时间: 2020
• 作者: Musicha P

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients.

• DOI: 10.1038/s41564-021-00879-y
• 发表时间: 2021-05
• 期刊: Nature microbiology
• 影响因子: 28.3
• 作者: León-Sampedro R;DelaFuente J;Díaz-Agero C;Crellen T;Musicha P;Rodríguez-Beltrán J;de la Vega C;Hernández-García M;R-GNOSIS WP5 Study Group;López-Fresneña N;Ruiz-Garbajosa P;Cantón R;Cooper BS;San Millán Á
• 通讯作者: San Millán Á

Carriage duration of carbapenemase-producing Enterobacteriaceae in a hospital cohort - implications for infection control measures

医院队列中产碳青霉烯酶肠杆菌科细菌的携带持续时间——对感染控制措施的影响

• DOI: 10.1101/19001479
• 发表时间: 2019
• 作者: Mo Y

Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study.

• DOI: 10.1371/journal.pntd.0006807
• 发表时间: 2018-09
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Cooper BS;White LJ;Siddiqui R
• 通讯作者: Siddiqui R