Deciphering Electron Transfer Pathways in Bacteria

酶催化的氧化反应是天然存在的生物活性分子的生产中的关键参与者。这些过程受到其电子转移伙伴的严格调控。该项目旨在从代谢多样性细菌中克隆新的电子转移铁氧还蛋白。这些铁氧还蛋白，在许多细菌中很重要，在它们的铁硫簇结合基序中含有不同的非半胱氨酸氨基酸，并且定义不明确。这些结果将促进对电子转移这一基本过程的理解。这将使战略，以打击人类和植物病原体和释放的潜力，这些系统作为生物催化剂的绿色化学合成的复杂和有价值的化学品。

Enzyme catalysed oxidation reactions are key players in the production of naturally occurring biologically active molecules. These processes are tightly regulated by their electron transfer partners. This project aims to characterise new electron transfer ferredoxin proteins from a metabolically diverse bacterium. These ferredoxins, important in many bacteria, contain different non-cysteine amino acids in their iron-sulfur cluster binding motifs and are poorly defined. The outcomes will advance understandings of electron transfer, a fundamental process. This will allow strategies to combat human and plant pathogens and unlock the potential of these systems as biocatalysts for the green chemical synthesis of complex and valuable chemicals.