Development and application of a Mendelian randomization framework aimed at dissecting the biological basis of ankylosing spondylitis and other complex diseases

孟德尔随机化框架的开发和应用，旨在剖析强直性脊柱炎和其他复杂疾病的生物学基础

• 批准号: nhmrc : 1125200
• 负责人: Prof David Evans
• 金额: $ 19.3万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-application-mendelian-complex-diseases/947527
• 关键词: Development; application; Mendelian; randomization; framework

Our aim is to identify genes and biological molecules that cause a type of autoimmune arthritis called ankylosing spondylitis. Our approach involves finding combinations of genes that are related to biological molecules of interest and then testing to see whether the gene combination is also related to risk of disease. We hope that our strategy will lead to new drug treatments targeting the condition.

我们的目标是确定基因和生物分子，导致一种称为强直性脊柱炎的自身免疫性关节炎。我们的方法包括找到与感兴趣的生物分子相关的基因组合，然后测试基因组合是否也与疾病风险相关。我们希望我们的策略将导致针对这种情况的新药物治疗。