HYPERPNEA AND PARENCHYMAL PATHOPHYSIOLOGY IN ASTHMA

高呼吸暂停(HP)对肺功能有重要影响。它刺激了 哮喘患者在运动或过度换气期间的支气管痉挛，并可能 通过灭活肺表面活性物质降低实质顺应性 动物。我们对这种对实质肺的影响很感兴趣。 当我们观察到外周阻力(Rp)上升和 在楔形模拟局部HP之后，外围设备遵从性下降 气道段有大流量的冷、干空气。这导致了一种假设 幽门螺杆菌通过以下方式影响人类的肺实质功能 机制：1)直接释放炎性介质导致RP升高； 2)对表面活性物质功能的直接影响。 目前的项目旨在探索生理学和 幽门螺杆菌对人体的生化影响，无论是正常的还是哮喘的。 具体地说，我们将通过以下方式寻找实质肺力学的变化 测量肺弹性反冲、顺应性和滞后，并与 这些对呼吸道功能的改变。我们还将把这些全肺 Rp参数的变化，并立即灌洗刺激的呼吸道 和部门，以评估介质和表面活性物质的变化，可能 跟随惠普发展。β-激动剂和外源性表面活性物质将 被赋予直接扰动系统的能力，以便建立 机制。最后，我们将确定PEEP和更改的影响 肺体积对实质力学的影响，以及肺体积与肺实质力学的相互依赖 实质和呼吸道。

Hyperpnea (HP) has important effects on lung function. It stimulates bronchospasm in asthmatics during exercise or hyperventilation, and may reduce parenchymal compliance through inactivation of surfactant in animals. We became intrigued with this effect on parenchymal lung mechanics when we observed that peripheral resistance (Rp) rises and peripheral compliance falls following simulated local HP in a wedged airway segment with high-flow cold,dry air. This led to the hypothesis that HP affects parenchymal lung.function in humans by the following mechanisms: 1) increased Rp due to direct inflammatory mediator release; and 2) direct effects on surfactant function. The current project is designed to explore the physiological and biochemical effects of HP in humans, both normal and asthmatic. Specifically, we will look for changes in parenchymal lung mechanics by measuring lung elastic recoil, compliance and hysteresis, and relate these changes to airway function. We will also relate these whole-lung parameters to changes in Rp, and immediately lavage the stimulated airway and segment to assess the changes in mediators and surfactant that may develop following HP. Beta-agonists and exogenous surfactant will then be given to directly perturbate the system in order to establish mechanism. Finally, we will determine the effects of PEEP and alterations in lung volume on parenchymal mechanics, and the interdependence of the parenchyma and airways.