OPTIMIZED FIBERS FOR THE INTRAVENOUS MEMBRANE OXYGENATOR

用于静脉膜式氧合器的优化纤维

• 批准号: 6142595
• 负责人: SCOTT B MCCRAY
• 金额: $ 10万
• 依托单位: BEND RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142595
• 关键词: adult respiratory distress syndrome; artificial membranes; biomaterial development /preparation; blood oxygenator; technology /technique development

The goal of this program is to develop hollow-fiber membranes and fiber fabrics that are customized for use in the Intravenous Membrane Oxygenator (IMO) under development at the University of Pittsburgh. The IMO is being developed as a method of augmenting incomplete respiration in adults with acute respiratory failure. Although the current versions of the IMO perform adequately, the gas-exchange rate of the IMO is not optimal. Specifically, the commercially available hollow-fiber membranes and fiber fabrics used in the IMO do not result in maximum membrane area in the device, limiting gas exchange. The goal of this program is to develop hollow-fiber membranes and fabrics specifically designed to optimize gas exchange in the IMO. In Phase I, we propose to develop hollow-fiber membranes with the optimum dimensions, strength, and permeability. We will work with researchers at the University of Pittsburgh to evaluate these fibers in a prototype IMO. Success in Phase I would lead to a Phase II program focused on optimization of the hollow-fiber membranes and fiber fabrics made from these membranes. Phase II would culminate with long-term tests of the prototype devices in animals at the University of Pittsburgh, demonstrating the effectiveness of the technology. PROPOSED COMMERCIAL APPLICATIONS: Development of the improved hollow-fiber membranes should make possible the practical application of the IMO. The membranes also promise to be useful for other commercial products, including extracorporeal oxygenators.

该计划的目标是开发中空纤维膜和纤维织物，用于匹兹堡大学正在开发的静脉膜式氧合器（IMO）。IMO正在开发作为一种增强患有急性呼吸衰竭的成人呼吸不完全的方法。虽然IMO的当前版本表现良好，但IMO的气体交换率并不是最佳的。具体地，在IMO中使用的市售中空纤维膜和纤维织物不会导致装置中的最大膜面积，从而限制了气体交换。该计划的目标是开发专门设计用于优化IMO气体交换的中空纤维膜和织物。在第一阶段，我们建议开发具有最佳尺寸、强度和渗透性的中空纤维膜。我们将与匹兹堡大学的研究人员合作，在原型IMO中评估这些纤维。第一阶段的成功将导致第二阶段计划的重点是优化中空纤维膜和由这些膜制成的纤维织物。第二阶段将在匹兹堡大学的动物中对原型设备进行长期测试，以证明该技术的有效性。建议的商业应用：改进的中空纤维膜的开发应使IMO的实际应用成为可能。这种膜也有望用于其他商业产品，包括体外氧合器。