PRODUCTION OF PYROGEN-FREE WATER IN HEMODIALYSIS UNIT
PRODUCTION OF PYROGEN-FREE WATER IN HEMODIALYSIS UNIT
批准号:
6143958
负责人:
ANUNCIA GONZALEZ-MARTIN
金额:
$9.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-07-01 至 2001-03-31
中文摘要
许多报告的风险和危害被确定为血液透析
英文摘要
Many of the reported risks and hazards identified for hemodialysis
are associated with water quality, including pyrogenic contamination.
The typical patient on dialysis is exposed to between 30 and 40 times
the amount of water to which a member of the general population
is exposed. Thus, the quality of hemodialysis water is obviously
very important. Current practices in hemodialysis systems does not guaranty
pyrogen-free water. Several drawbacks exist in the use of available procedures
to achieve pyrogen-free water: (i) addition of chemicals, which have to be
monitored and destroyed before the water contacts the dialysis membrane.
Otherwise, the chemicals come in contact with the patients blood; (ii)
formation of toxic by-products from the reaction with the disinfectant: (iii)
no on-line supply of pyrogen-free water (i.e., batch-mode operation), and (iv)
cost. This project pursues the development of an efficient, fast, and
cost-effective reactor to supply pyrogen-free water on-line in
hemodialysis systems. The disinfecting agents are hydroxyl radicals, one of the
strongest oxidants, which are produced in situ, and consumed inside the
reactor. The aim of this Phase I is to evaluate the technical feasibility
of a noval device for on-line production of pyrogen-free water. During
the Phase II, an automatic system will be developed and integrated in
hemodialysis systems.
PROPOSED COMMERCIAL APPLICATION:
Pyrogen-free water is required in all hemodialysis systems. In addition, large quantities of
pyrogen-free water are used by the medical industry such as in intravenous infusion fluids,
fluids for infection and for irrigation in operating rooms. Also, sterile water is needed in the hydroponics industry.
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批准号:6211121
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Production of Pyrogen-Free Water in Hemodialysis Units
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批准号:6622294
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财政年份:1999
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项目类别:
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资助金额:$40.76万
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财政年份:1999
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依托单位: