DEVICE FOR SIMULTANEOUS ABR/OAE ACQUISITION

在第一阶段，研究并论证了ABR-TEOAE同步采集系统的可行性。收集了12名成年人的数据并进行了离线处理。进行了三个实验。实验1验证了采用线性、非线性、交替和非交替刺激同时获取ABR和TEOAE的可行性。在实验2中，实现了一种替代的刺激伪影消减方法——缩放模板减法（STS），并成功地进行了测试。实验表明，与目前用于获取teoae的导出非线性方法相比，线性刺激与STS方法相结合至少有三个优点：a)提供更准确的伪阈值，b)减少人工污染，c)提供更有效的数据采集。实验3测试了一种跨模态噪声消除技术，并证明同时使用EEG和声学输入的噪声水平可以提高OAE和ABR的信噪比。在第二阶段，这些技术将实时实施，并扩展到包括纯音刺激。同时，还将开发一种具有更宽频率和强度范围的新型探头，并配有刺激伪影抵消前置放大器。二年级将进行临床试验，以测试该系统在一系列操作条件下的性能，包括术中监测和婴儿听力筛查。拟议的商业应用：拟议的TEOAE /ABR系统将使临床医生能够同时使用TEOAE和ABR来评估听力状况。先进的刺激伪影消除方法将提高伪阈值测定和测试效率，减少刺激伪影污染。该设备将在听力测试的所有领域立即获得商业应用。

During Phase I, the feasibility of a simultaneous ABR-TEOAE acquisition system was studied and demonstrated. Data from 12 adults were collected and processed off-line. Three experiments were conducted. In experiment l, the feasibility of simultaneous ABR and TEOAE acquisition using linear, non-linear, alternating and non-alternating stimuli was demonstrated. In experiment 2, an alternative stimulus artifact reduction method, Scaled Template Subtraction (STS), was implemented and tested successfully. The experiment showed that linear stimulation combined with the STS method has at least three advantages over the current Derived Non-Linear Method used to acquire TEOAEs: it a) provides more accurate pseudo-thresholds, b) reduces artifact contamination, and c) provides for more efficient data acquisition. Experiment 3 tested a cross-modality noise cancellation technique and demonstrated that both OAE and ABR signal- to-noise ratios can be improved by using noise levels from EEG and acoustic inputs simultaneously. During Phase II, these techniques will be implemented in real-time and expanded to include pure tone stimulation. A new probe with a broader frequency and intensity range and stimulus artifact canceling preamplifier will also be developed. Clinical trials will be conducted in Year 2 to test the system under a range of operating conditions, including intraoperative monitoring and infant hearing screening. PROPOSED COMMERCIAL APPLICATION: The proposed TEOAE /ABR system will enable clinicians to evaluate hearing status using both TEOAEs and ABRs simultaneously. Advanced stimulus artifact cancellation methods will improve pseudo-threshold determination and testing efficiency and reduce stimulus artifact contamination. The proposed device will find immediate commercial application in all areas of hearing testing.