The Simultaneous Acquisition of Auditory Transient and Steady State Evoked Potent

听觉瞬态和稳态诱发电位的同时获取

• 批准号: 8453697
• 负责人: Rafael E Delgado
• 金额: $ 15万
• 依托单位: INTELLIGENT HEARING SYSTEMS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453697
• 关键词: Adult; Algorithms; Auditory; Auditory Brainstem Responses; Auditory Evoked Potentials; Auditory system; Calibration; Clinical Research; Collaborations; Complex; Computer software; Data; Data Analyses; Data Display; Detection; Development; Devices; Diagnostic; Disadvantaged; Ear; Elements; Evaluation; Evoked Potentials; Frequencies; Generations; Hearing; Individual; Infant; Judgment; Length; Methods; Pathology; Patients; Phase; Procedures; Process; Public Health; Resolution; Response Latencies; Sampling; Stimulus; System; Techniques; Test Result; Testing; Time; Universities; Validation; Width; Work; clinical application; commercialization; design; hearing impairment; novel; public health relevance; relating to nervous system; response; young adult

DESCRIPTION (provided by applicant): This project aims to develop a device capable of acquiring transient and steady state auditory evoked potenlatials (AEPs) simultaneously using an efficient and advanced processing technique. The proposed technique will be implemented as a software module on Intelligent Hearing Systems' (IHS) evoked potential system platform. Auditory Transient Responses (ATRs) are typically elicited using short duration stimuli and include Auditory Brainstem Responses (ABRs), Middle Latency Responses (MLRs) and Late Latency Responses (LLRs). Auditory Steady State Responses (ASSRs) are elicited using long duration stimuli and represent continuous evoked activity. Currently, ATR and ASSR data are recorded independently, using either different software modules or different devices, and the resulting data are analyzed and presented independently. As a result, testing time is prolonged and it may be difficult to reconcile data because of differences in stimulation technique, calibration and patient status between tests. A new method of acquiring ATRs and ASSRs simultaneously has been developed by Intelligent Hearing Systems. The technique uses sets of special stimulation sequences that can be deconvolved to extract ATRs while averaging the sets together results in true ASSRs. Unlike previous deconvolution techniques, such as Maximum Length Sequences (MLS), which required complex non-periodic stimuli for deconvolution, the proposed technique uses a more recently developed method, Continuous Loop Averaging Deconvolution (CLAD), which utilizes nearly isosynchronous sequences. By combining sets of nearly isosynchrnous sequences, the simultaneous acquisition of ATRs and ASSRs is accomplished. The benefits of acquiring both ATRs and ASSRs simultaneously are numerous: 1) Provide unique information from each type of response without increasing test time, 2) Eliminate patient state differences between recording procedures, 3) Eliminate problems associated with use of different stimuli and calibration, and 4) Facilitate interpretation of data by providing all results on one user interface. During Phase I, work will be conducted to optimize and test the proposed simultaneous technique by comparing results with conventional ATRs and ASSRs using click and frequency specific stimuli on 10 young adult subjects. During Phase II, the work will be expanded and a larger clinical study conducted including infants and adults of various hearing loss configurations. The device is expected to have immediate commercialization potential as an add-on software module for the thousands of current IHS users and new potential users as well.

描述（由申请人提供）：本项目旨在开发一种能够同时获取瞬态和稳态听觉诱发电位（AEPs）的设备，采用高效和先进的处理技术。该技术将作为智能听力系统（IHS）诱发电位系统平台的软件模块实现。听觉瞬态反应（ATRs）通常由短时刺激引起，包括听觉脑干反应（ABRs）、中潜伏期反应（MLRs）和晚潜伏期反应（LLRs）。听觉稳态反应（ASSRs）是使用长时间刺激引起的，代表连续的诱发活动。目前，ATR和ASSR数据是独立记录的，使用不同的软件模块或不同的设备，并独立分析和呈现结果数据。结果，由于刺激技术、校准和患者状态的差异，测试时间延长，并且可能难以调和数据。智能听力系统开发了一种同时获取atr和assr的新方法。该技术使用一系列特殊的刺激序列，这些序列可以反卷积来提取atr，同时将这些序列平均起来得到真正的assr。与之前的反褶积技术不同，例如最大长度序列（MLS）需要复杂的非周期刺激来进行反褶积，该技术使用了最近开发的方法，连续循环平均反褶积（CLAD），该方法利用了几乎等同步的序列。通过组合近等同步序列集，实现了atr和assr的同时采集。同时获取atr和assr的好处很多：1)在不增加测试时间的情况下提供每种类型反应的独特信息，2)消除记录程序之间的患者状态差异，3)消除与使用不同刺激和校准相关的问题，4)便于解释