Yoga programme for type-2 diabetes prevention (YOGA-DP) among high-risk people in India: intervention development and feasibility study

印度高危人群预防 2 型糖尿病瑜伽项目 (YOGA-DP)：干预措施开发和可行性研究

• 批准号: MR/R018278/1
• 负责人: Kaushik Chattopadhyay
• 金额: $ 16.19万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR018278%2F1
• 关键词: Yoga; programme; type; diabetes; prevention

Diabetes (type-2) is a complex metabolic disorder with significant health, social and economic consequences. India has the world's second largest diabetic population. Another huge population in India is at high-risk of developing diabetes, i.e., their blood sugar levels are higher than normal but lower than the established threshold for diabetes itself. They are more likely to develop diabetes and its complications than people with normal blood sugar levels. Physical activity reduces blood sugar levels. However, physical activity levels are lower among Indians, especially among women and older people. Contemporary physical activities have some limitations, which includes their poor acceptability. Yoga, a mind-body discipline that originated in the Indian subcontinent, has some advantages over contemporary physical activities and can meet the aim of the recommended physical activity for diabetes prevention among high-risk people in India (target users).The main aim is to establish whether or not a yoga programme can prevent diabetes among high-risk people in India. This will be tested in a future main study. Before this, we will develop the programme content and will check with our study participants if the future main study can be conducted. This early phase study will be carried out in New Delhi, India - a huge population in New Delhi is at high-risk of developing diabetes.Qualified yoga practitioners will provide group yoga sessions, for 75 minutes, twice a week for six months at local community centres. The development of the programme content will include several steps, such as a systematic review of scientific literature to generate a list of yogic practices that are recommended for managing diabetes. Subsequently, at least 40 experts (yoga and exercise professionals) will validate each of these yogic practices. Based on this, the programme will be drafted and pre-tested among 20-30 target users, recruited using a multipronged approach (i.e., from the community as well as public and private healthcare providers). Yoga practitioners will provide the programme to them, followed by qualitative interviews to improve the programme. Once the programme details are finalised, a study will be conducted among at least 64 target users, to check if the future main study can be conducted. They will be randomly allocated either to the yoga programme group or the control group. The control group participants will receive enhanced standard care, i.e., a leaflet and a group session on routine physical activity advice. The multipronged approach will be used to recruit them. Quantitative data (numerical) will be collected and analysed on study-specific issues, such as a quantity which is needed to estimate study size of the future main study, recruitment and follow-up of participants, and attendance of yoga programme group participants in the yoga programme. Qualitative interviews will take place with 20-30 participants to explore how they have found participating in the study and any particular issues experienced. Those who decline to participate in the study will be interviewed to explore the reasons behind. If the feasibility of undertaking the future main study is promising, the main study will be conducted. If the yoga programme is found to be effective, it will be a low-cost local solution to prevent diabetes among high-risk people in India and to become healthier overall. The future clinical, personal and economic burden of diabetes on patients and their families will be prevented. The benefits of preventing diabetes may extend to the prevention of its complications. They will be provided with more evidence-based choices to meet the recommended physical activity for diabetes prevention. The programme will simultaneously empower participants to manage their health.

糖尿病（2型）是一种复杂的代谢紊乱，具有显著的健康、社会和经济后果。印度拥有世界第二大糖尿病人口。印度另一个庞大的人口患糖尿病的风险很高，即，他们的血糖水平高于正常水平，但低于糖尿病本身的既定阈值。他们比血糖水平正常的人更容易患糖尿病及其并发症。身体活动降低血糖水平。然而，印度人的体育活动水平较低，特别是妇女和老年人。现代体育活动存在一定的局限性，包括其可接受性差。瑜伽是起源于印度次大陆的一种身心训练，与当代体育活动相比具有一些优势，可以满足印度高风险人群（目标用户）预防糖尿病的推荐体育活动的目标，主要目的是确定瑜伽课程是否可以预防印度高风险人群的糖尿病。这将在未来的主要研究中进行测试。在此之前，我们将制定计划内容，并与我们的研究参与者核实是否可以进行未来的主要研究。这项早期研究将在印度的新德里进行--新德里有大量的人口处于糖尿病的高风险中。合格的瑜伽练习者将在当地社区中心提供每周两次、每次75分钟的瑜伽集体课程，为期六个月。该计划内容的开发将包括几个步骤，例如对科学文献进行系统审查，以生成推荐用于管理糖尿病的瑜伽练习列表。随后，至少有40名专家（瑜伽和运动专业人士）将验证这些瑜伽练习。在此基础上，将起草该方案，并在20-30个目标用户中进行预先测试，这些用户是采用多管齐下的方法招募的（即，来自社区以及公共和私人医疗保健提供者）。瑜伽练习者将向他们提供该计划，然后进行定性访谈以改进该计划。待计划细节敲定后，将对至少64名目标用户进行研究，以确定未来是否可以进行主要研究。他们将被随机分配到瑜伽课程组或对照组。对照组受试者将接受加强的标准护理，即，一份关于日常体育活动建议的传单和一次小组会议。将采用多管齐下的方法来招募他们。将收集和分析研究特定问题的定量数据（数字），例如估计未来主要研究的研究规模所需的数量，参与者的招募和随访，以及瑜伽课程组参与者参加瑜伽课程的情况。将对20-30名参与者进行定性访谈，以探讨他们如何发现参与研究以及经历的任何特定问题。那些拒绝参加这项研究的人将接受采访，以探讨背后的原因。如果进行未来主要研究的可行性很有希望，将进行主要研究。如果瑜伽项目被发现是有效的，它将是一个低成本的地方解决方案，以预防印度高风险人群的糖尿病，并使整体变得更健康。糖尿病对患者及其家庭的未来临床、个人和经济负担将得到预防。预防糖尿病的好处可能会扩展到预防其并发症。他们将获得更多基于证据的选择，以满足预防糖尿病的推荐体力活动。该方案将同时使参与者能够管理自己的健康。

项目成果

Yoga Program for Type 2 Diabetes Prevention (YOGA-DP) Among High-Risk People: Qualitative Study to Explore Reasons for Non-participation in a Feasibility Randomized Controlled Trial in India.

• DOI: 10.3389/fpubh.2021.682203
• 发表时间: 2021
• 期刊: Frontiers in public health
• 影响因子: 5.2
• 作者: Mishra P;Greenfield SM;Harris T;Hamer M;Lewis SA;Singh K;Nair R;Mukherjee S;Krishnamurthy Manjunath N;Harper DR;Tandon N;Kinra S;Prabhakaran D;Chattopadhyay K
• 通讯作者: Chattopadhyay K

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): A Qualitative Study Exploring the Trial Team's Facilitators and Challenges in Conducting a Feasibility Trial in India.

• DOI: 10.1007/s13300-023-01450-0
• 发表时间: 2023-10
• 期刊: DIABETES THERAPY
• 影响因子: 3.8
• 作者: Mishra, Pallavi;Greenfield, Sheila Margaret;Harris, Tess;Hamer, Mark;Lewis, Sarah Anne;Singh, Kavita;Nair, Rukamani;Mukherjee, Somnath;Tandon, Nikhil;Kinra, Sanjay;Manjunath, Nandi Krishnamurthy;Prabhakaran, Dorairaj;Chattopadhyay, Kaushik
• 通讯作者: Chattopadhyay, Kaushik

Feasibility Trial of Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP) among High-Risk People in India: A Qualitative Study to Explore Participants' Trial- and Intervention-Related Barriers and Facilitators.

• DOI: 10.3390/ijerph19095514
• 发表时间: 2022-05-01
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Mishra, Pallavi;Harris, Tess;Greenfield, Sheila Margaret;Hamer, Mark;Lewis, Sarah Anne;Singh, Kavita;Nair, Rukamani;Mukherjee, Somnath;Manjunath, Nandi Krishnamurthy;Tandon, Nikhil;Kinra, Sanjay;Prabhakaran, Dorairaj;Chattopadhyay, Kaushik
• 通讯作者: Chattopadhyay, Kaushik

IDF21-0070 Yoga programme for type 2 diabetes prevention (YOGA-DP) among high-risk people in India: a multi-centre feasibility RCT

IDF21-0070 印度高危人群预防 2 型糖尿病的瑜伽项目 (YOGA-DP)：多中心可行性随机对照试验

• DOI: 10.1016/j.diabres.2022.109457
• 发表时间: 2022
• 期刊: Diabetes Research and Clinical Practice
• 影响因子: 5.1
• 作者: Chattopadhyay K

Development of a Yoga Program for Type-2 Diabetes Prevention (YOGA-DP) Among High-Risk People in India.

• DOI: 10.3389/fpubh.2020.548674
• 发表时间: 2020
• 期刊: Frontiers in public health
• 影响因子: 5.2
• 作者: Chattopadhyay K;Mishra P;Manjunath NK;Harris T;Hamer M;Greenfield SM;Wang H;Singh K;Lewis SA;Tandon N;Kinra S;Prabhakaran D
• 通讯作者: Prabhakaran D