CRAVING AND CUE REACTIVITY IN ADOLESCENT ALCOHOLICS

青少年酗酒者的渴望和提示反应

• 批准号: 2893712
• 负责人: Suzanne E Thomas
• 金额: $ 7.2万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2893712
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; craving; cues; human subject; photography; visual stimulus

APPLICANT'S ABSTRACT: Alcohol abuse and alcoholism are problems that are becoming increasingly more prevalent in adolescents. While continued efforts are being made to prevent alcohol use among youth, thereby preventing abuse and/or dependence, there is also the need to provide effective treatments for adolescents who have already become dependent on alcohol. Treatment for adult alcoholics has made substantial progress in the past two decades. For example, there are specific psychotherapies (e.g., cue-exposure therapy) and pharmacotherapies (e.g., opiate antagonists) that may reduce craving and help the adult alcoholic resist urges to drink. These treatments have not been widely used in adolescent alcoholics, in part because it is not known whether adolescents crave alcohol as adults do. The present study is proposed to address this void by first developing the alcohol cues needed to assess craving and cue-induced reactivity in adolescents. The goal of Phase 1 is to gather information about visual cues that may elicit urges to drink in adolescent alcoholics. These cues will be photographed and developed into 35 mm slides. The slides will be tested in Phase 2, and adolescent alcoholics will report which subset of the slides produced the greatest urge to drink. In Phase 3, alcoholic adolescents and matched controls will be compared on how they respond to these photographic slides. It is hypothesized that the alcoholic group will show greater cue-induced reactivity and report greater subjective craving than will the control group. The results of the study will guide future efforts to understand the nature of adolescent alcoholism, whether adolescents crave, and if so, possible treatments for this population.

申请者摘要：酗酒和酗酒是 在青少年中变得越来越普遍。在继续努力的同时 是为了防止年轻人饮酒，从而防止滥用 和/或依赖，还需要提供有效的治疗 已经对酒精产生依赖的青少年。 在过去的两年中，成人酗酒者的治疗取得了实质性进展。 几十年。例如，有特定的心理治疗(例如，线索暴露 治疗)和药物疗法(如阿片类拮抗剂)可减少 帮助成年酗酒者抑制饮酒欲望。 这些疗法还没有被广泛应用于青少年酗酒者，部分原因是 因为目前还不知道青少年是否像成年人一样渴望饮酒。这个 目前的研究建议通过首先开发酒精来解决这一空白 需要线索来评估青少年的渴望和线索诱导的反应。这个 第一阶段的目标是收集有关视觉线索的信息，这些线索可能会引发 青少年酗酒者的饮酒冲动。这些线索将被拍摄下来并 发展成35毫米的幻灯片。幻灯片将在第二阶段进行测试，以及 青少年酗酒者将报告哪些幻灯片子集产生了 最强烈的饮酒欲望。在第三阶段，酗酒青少年和匹配的对照组 将比较他们对这些摄影幻灯片的反应。它是 假设酒精组将表现出更大的线索诱导的反应性 与对照组相比，报告的主观渴望更大。 这项研究的结果将指导未来的努力，以了解 青少年酗酒，青少年是否渴望，如果是，是否可能 对这一人群的治疗。