HIV/SIV STRUCTURAL GENE VECTORS AS A LIVE HIV VACCINE
HIV/SIV STRUCTURAL GENE VECTORS AS A LIVE HIV VACCINE
批准号:
2799594
负责人:
Kathleen A. Boris-Lawrie
金额:
$3.65万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-05-01 至 1999-07-31
中文摘要
描述(改编自申请人摘要):一个成功的HIV
英文摘要
DESCRIPTION (adapted from applicant's abstract): A successful HIV
vaccine must induce a protective HIV-specific CTL response. A live-
attenuated HIV vaccine provides a promising strategy to boost the HIV-
specific CTL response. Genetically simple derivatives of HIV-l have been
proposed as a novel approach to a safe live-attenuated HIV vaccine. The
project is based on the hypothesis that infection with HIV
structural genes vectors (SGV) provides protective immunity against
infection with diverse strains of HIV. The SGV are unique retrovirus
vectors that express replication-competent viruses composed of the HIV
structural proteins, but lack HIV genes associated with pathogenesis.
Because of their unique genetic structure, the SGV are Tat-independent
and constitutively replicate HIV gag, pot, env, and a minimal complement
of accessory genes. Replication of the SGV provides natural presentation
of HIV structural proteins in antigen presenting cells, which assures
optimal stimulation of cell-mediated immunity through MHC class I and
class II presentation. Limited cycles of replication generate genetic
variants important for induction of immunity against diverse strains of
HIV, but minimize the chance of a deleterious insertion or recombination
event. The HIV SGV are based on prototypic bovine leukemia virus (BLV)
SGV that are infectious, immunogenic, and lack pathogenicity in two BLV
animal models. The overall goal of this study is to test the hypothesis
that SGV are infectious and immunogenic in the surrogate SIV monkey
model for AIDS and B-cell Iymphoma. The specific aims are: 1) to define
the minimal combination of HIV accessory genes necessary for efficient
replication of HIV SGV in cultured and primary cells; 2) to develop
similar SIV SGV that replicate efficiently in cultured and primary
cells; 3) to evaluate the infectivity and immunogenicity of the SIV SGV
in the macaque model.
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HIV-1 cap epigenetic modification
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批准号:10866730
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财政年份:2023
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依托单位:
Characterization of RHA:RT interactions in HIV-1 reverse transcription
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批准号:10403061
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资助金额:$26.25万
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财政年份:2022
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依托单位:
Characterization of RHA:RT interactions in HIV-1 reverse transcription
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批准号:10614580
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项目类别:
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资助金额:$19.52万
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财政年份:2022
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负责人:Kathleen A. Boris-Lawrie
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依托单位:
The Center for HIV RNA Studies (CRNA)
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批准号:8512891
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项目类别:
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资助金额:$21.71万
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财政年份:2012
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负责人:Kathleen A. Boris-Lawrie
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依托单位:
Translational Control of Retroviral Unspliced mRNA
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批准号:7039375
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项目类别:
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资助金额:$20.35万
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财政年份:2006
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负责人:Kathleen A. Boris-Lawrie
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依托单位:
Translational Control of Retroviral Unspliced mRNA
-
批准号:7339629
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2006
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负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Translational Control of Retroviral Unspliced mRNA
-
批准号:7544521
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2006
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Translational Control of Retroviral Unspliced mRNA
-
批准号:7996196
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2006
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Translational Control of Retroviral Unspliced mRNA
-
批准号:7176238
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2006
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Retrovirus Models of Cellular Post-transcriptional Gene Expression
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批准号:8079529
-
项目类别:
-
资助金额:$20.75万
-
财政年份:2003
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Retrovirus Models of Cellular Post-transcriptional Gene Expression
-
批准号:8376222
-
项目类别:
-
资助金额:$20.0万
-
财政年份:2003
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Retrovirus Models of Cellular Post-transcriptional Gene Expression
-
批准号:8299996
-
项目类别:
-
资助金额:$20.12万
-
财政年份:2003
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Retrovirus Models of Cellular Post-transcriptional Gene Expression
-
批准号:7383667
-
项目类别:
-
资助金额:$14.69万
-
财政年份:2003
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
Retrovirus Models of Cellular Post-transcriptional Gene Expression
-
批准号:7876676
-
项目类别:
-
资助金额:$20.34万
-
财政年份:2003
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
INDUCTION OF ANTIVIRAL IMMUNITY
-
批准号:6364001
-
项目类别:
-
资助金额:$4.03万
-
财政年份:2000
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
INDUCTION OF ANTIVIRAL IMMUNITY
-
批准号:6531180
-
项目类别:
-
资助金额:$4.03万
-
财政年份:2000
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
INDUCTION OF ANTIVIRAL IMMUNITY
-
批准号:6053592
-
项目类别:
-
资助金额:$3.8万
-
财政年份:2000
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
HIV STRUCTURAL GENE VECTORS--LIVE ATTENUATED HIV VACCINE
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批准号:6021286
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项目类别:
-
资助金额:$21.9万
-
财政年份:1999
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
HIV STRUCTURAL GENE VECTORS--LIVE-ATTENUATED HIV VACCINE
-
批准号:6170687
-
项目类别:
-
资助金额:$21.9万
-
财政年份:1999
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
RNA TRAFFICKING IN SIMPLIFIED HIV1 DERIVATIVES
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批准号:6170004
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项目类别:
-
资助金额:$10.32万
-
财政年份:1997
-
负责人:Kathleen A. Boris-Lawrie
-
依托单位:
国内基金
海外基金
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