Investigation of the generation and functional maturation of regulatory T cells in vivo
调节性T细胞体内生成和功能成熟的研究
基本信息
- 批准号:MR/S000208/1
- 负责人:
- 金额:$ 62.81万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project aims to reveal the fundamental molecular mechanisms of immunological tolerance at the gene level. Immunological tolerance is a unique attribute of the adaptive immune system and suppresses excessive or unnecessary immune responses and thereby prevents the development of autoimmune disease and allergy. It is also important in the development of cancer, as the mechanisms of immunological tolerance suppress anti-tumour immunity, and thereby contribute to the development of malignancies. Regulatory T cells (Treg) are a central player of immunological tolerance. Treg suppress the activities of other T cells and thereby prevent and resolve the T cell response. Treg have been extensively studied in basic and clinical immunology, and they play roles in suppressing unwanted immune responses in autoimmune diseases, allergy, organ transplant rejection. On the other hand, the depletion of Treg can increase anti-tumour immunity. However, the suppressive mechanism of Treg is not fully known, and this lack of understanding prevents the effective application of Treg-mediated immune regulation to clinical practice.The transcription factor Foxp3 is the key factor of Treg: it controls Treg differentiation and is required for the suppressive activity of Treg. Thus, although the suppressive mechanism of Treg is not fully known, it is a promising approach to investigate the molecular mechanisms of Foxp3-mediated T cell regulation. In this project, we will investigate the molecular mechanisms of how Foxp3 controls the suppressive function of Treg at gene level, and how T cell response to antigens promote the differentiation and maturation of Treg.The project aims to obtain transferable knowledge and technology to industry, including the pharmaceutical industry.The understanding of the mechanism of immunological tolerance and the suppressive mechanisms of Treg at the gene level is important not only for scientific progress but also for patency and for the development of new immunosuppressive drugs and vaccines. We also aim to use the findings of the project to improve the efficiency of the screening processes in the development of new drugs. The findings of this study will benefit broad scientific communities and contribute to health and well-being of humans and animals. In addition, this study will provide novel frameworks for systems biology, which can be used in many biological areas.
该项目旨在从基因水平揭示免疫耐受的基本分子机制。免疫耐受是适应性免疫系统的独特属性,可以抑制过度或不必要的免疫反应,从而防止自身免疫性疾病和过敏的发生。它在癌症的发展中也很重要,因为免疫耐受机制抑制抗肿瘤免疫,从而有助于恶性肿瘤的发展。调节性T细胞(Treg)是免疫耐受的核心参与者。Treg抑制其他T细胞的活性,从而防止和解决T细胞应答。Treg在基础免疫学和临床免疫学中得到了广泛的研究,在自身免疫性疾病、变态反应、器官移植排斥反应中发挥抑制免疫应答的作用。另一方面,Treg的耗竭可以增加抗肿瘤免疫力。然而,Treg的抑制机制尚不完全清楚,这种缺乏了解阻碍了Treg介导的免疫调节在临床实践中的有效应用。转录因子Foxp3是Treg的关键因子:它控制Treg的分化,并且是Treg的抑制活性所必需的。因此,虽然Treg的抑制机制还不完全清楚,但它是研究Foxp3介导的T细胞调节的分子机制的有希望的方法。本项目将从基因水平研究Foxp3调控Treg抑制功能的分子机制,以及T细胞对抗原的应答如何促进Treg的分化和成熟,旨在获得可转移的知识和技术,包括制药行业。在基因水平上对免疫耐受机制和Treg抑制机制的理解,这不仅对科学进步,而且对通畅性和新的免疫抑制药物和疫苗的开发都很重要。我们还打算利用该项目的研究结果来提高新药开发中筛选过程的效率。这项研究的结果将有利于广泛的科学界,并有助于人类和动物的健康和福祉。此外,这项研究将为系统生物学提供新的框架,可用于许多生物学领域。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade
免疫检查点阻断下肿瘤反应性 T 细胞的单细胞水平时间分析
- DOI:10.1101/2022.07.19.500582
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Hassan J
- 通讯作者:Hassan J
T-cell dysregulation in COVID-19.
- DOI:10.1016/j.bbrc.2020.10.079
- 发表时间:2021-01-29
- 期刊:
- 影响因子:3.1
- 作者:Kalfaoglu B;Almeida-Santos J;Tye CA;Satou Y;Ono M
- 通讯作者:Ono M
Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system
- DOI:10.2142/biophysico.bppb-v21.s010
- 发表时间:2024-01-01
- 期刊:
- 影响因子:1.5
- 作者:Ono,Masahiro
- 通讯作者:Ono,Masahiro
Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation
- DOI:10.1101/2022.07.21.500987
- 发表时间:2022-07
- 期刊:
- 影响因子:0
- 作者:José Almeida-Santos;Rita Berkachy;C. A. Tye;J. Hassan;B. Kalfaoglu;M. Selkirk;M. Ono
- 通讯作者:José Almeida-Santos;Rita Berkachy;C. A. Tye;J. Hassan;B. Kalfaoglu;M. Selkirk;M. Ono
Restoring control over autoimmunity by inducing Foxp3.
通过诱导 Foxp3 恢复对自身免疫的控制。
- DOI:10.1038/s41590-021-01008-x
- 发表时间:2021
- 期刊:
- 影响因子:30.5
- 作者:Ono M
- 通讯作者:Ono M
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Masahiro Ono其他文献
Development of 111In-labeled Exendin-4 derivative for the imaging of GLP-1R receptor expression in pancreatic islets
开发 111In 标记的 Exendin-4 衍生物,用于胰岛 GLP-1R 受体表达成像
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Hiroyuki Kimura;Kaori Kanbe;Hirokazu Matsuda;Kentaro Toyoda;Hiroyuki Fujimoto;Masahiro Ono;Nobuya Inagaki;Hideo Saji - 通讯作者:
Hideo Saji
(研究ノート)クルスス・プブリクスの統制と運用 : 後期ローマ帝国下における地中海世界の結合性をめぐって
(研究笔记)“Cursus Publicus”的控制与运作:关乎晚期罗马帝国下地中海世界的连通性
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Hiroyuki Watanabe;Masahiro Ono;Hiroyuki Kimura;Morio Nakayama;Hideo Saji;Takehisa Kumakawa;Takehisa Kumakawa;Takehisa Kumakawa;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;久山雄甫;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;久山雄甫;Yuho HISAYAMA;南雲 泰輔;南雲 泰輔 - 通讯作者:
南雲 泰輔
ルティリウス・ナマティアヌスとクルスス・プブリクス : 後期ローマ帝国における公的伝達システム運用の一側面
Rutilius Namatianus 和 Cursus Publicus:罗马帝国晚期公共通信系统运作的一个方面
- DOI:
- 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Hiroyuki Watanabe;Masahiro Ono;Hiroyuki Kimura;Morio Nakayama;Hideo Saji;Takehisa Kumakawa;Takehisa Kumakawa;Takehisa Kumakawa;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;久山雄甫;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;Yuho HISAYAMA;久山雄甫;Yuho HISAYAMA;南雲 泰輔;南雲 泰輔;南雲泰輔;南雲泰輔;南雲泰輔;南雲泰輔 - 通讯作者:
南雲泰輔
βアミロイドのPET/SPECT分子イメージングプローブの開発(次世代の薬効評価系を目指した新しい光学技術)
开发β-淀粉样蛋白PET/SPECT分子成像探针(针对下一代药效评价系统的新型光学技术)
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
Yan Cheng;Masahiro Ono;Hiroyuki Kimura;Shinya Kagawa;Ryuichi Nishii;Hidekazu Kawashima;Hideo Saji;小野正博 - 通讯作者:
小野正博
Novel Radioiodinated 1,3,4-Oxadiazole Derivatives with Improved in Vivo Properties for SPECT Imaging of β-Amyloid Plaques
新型放射性碘标记 1,3,4-恶二唑衍生物,具有改进的体内特性,可用于 β-淀粉样蛋白斑块的 SPECT 成像
- DOI:
10.1039/c3md00189j - 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Hiroyuki Watanabe;Masahiro Ono;Hiroyuki Kimura;Kenji Matsumura;Masashi Yoshimura;Shimpei Iikuni;Yoko Okamoto;Masafumi Ihara;Ryosuke Takahashi;Hideo Saji - 通讯作者:
Hideo Saji
Masahiro Ono的其他文献
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{{ truncateString('Masahiro Ono', 18)}}的其他基金
Elucidation of the transcriptional programme of memory T cells by a systems approach
通过系统方法阐明记忆 T 细胞的转录程序
- 批准号:
BB/J013951/2 - 财政年份:2015
- 资助金额:
$ 62.81万 - 项目类别:
Fellowship
Elucidation of the transcriptional programme of memory T cells by a systems approach
通过系统方法阐明记忆 T 细胞的转录程序
- 批准号:
BB/J013951/1 - 财政年份:2013
- 资助金额:
$ 62.81万 - 项目类别:
Fellowship
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利用功能表面建立气泡捕获、传输和生成技术并研究多相流中的流动和传热机制
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