FUNCTIONAL MRI OF THE HUMAN HIPPOCAMPUS

人类海马体的功能性 MRI

• 批准号: 6185147
• 负责人: MICHAEL M ZEINEH
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6185147
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; digital imaging; entorhinal cortex; functional magnetic resonance imaging; hippocampus; human subject; image enhancement; memory

DESCRIPTION (Adapted from applicant's abstract): The goal of this project is to better define the functional anatomy of the human hippocampus in memory processing with fMRI. This project proposes to perform high-resolution structural imaging studies of the hippocampal region, examining activity in the CA fields, subiculum, and entorhinal cortex throughout the anterior-posterior axis bilaterally, during performance of several memory paradigms in normal volunteers. Using computational techniques, the applicant will unfold the hippocampus to provide a flattened functional map of its activity. This research aims to elucidate the functional organization of substructures within the hippocampus in the intact brain. This knowledge will also impact the understanding and treating of diseases involving the hippocampus such as Alzheimer's disease and temporal lobe epilepsy. There will be three phases to this research: 1) The technology will be developed and optimized for the high-resolution imaging and segmentation of the hippocampus. 2) Stimulus paradigms will be developed with the goal of achieving differential hippocampal activity. 3) In order to identify structure-function relationships, these paradigms will be combined with the high-resolution imaging technology to deliver functional flattened maps of hippocampal activity.

描述(摘自申请者的摘要)：本项目的目标 是为了更好地定义人类海马体的功能解剖 使用功能磁共振成像进行记忆处理。该项目建议执行 海马区的高分辨率结构成像研究， 检查CA区、下丘脑和内嗅皮层的活动 在双侧前-后轴的整个过程中 正常志愿者的几种记忆范式。使用计算性 技术，申请者将展开海马体，以提供扁平的 其活动的功能图。这项研究旨在阐明 大鼠海马区亚结构的功能组织 完整的大脑。这一知识也将影响人们对 阿尔茨海默病等涉及海马体的疾病的治疗 和颞叶癫痫。 这项研究将分为三个阶段：1)技术将 开发并优化了高分辨率成像和分割 海马体。2)将制定刺激范例，目标是 实现不同的海马区活动。3)为了识别 结构-功能关系，这些范例将与 高分辨率成像技术，可提供功能性平面化地图 海马区活动。