Identification of Metabolic Phenotypes and Systemic Biochemical Reaction Networks Associated with Human Blood Pressure

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High blood pressure is an important component of metabolic syndrome and one of the most common modifiable risk factors for human cardiovascular disease and non-communicable disease. High blood pressure remains to be the leading cause for global disease burden and is estimated to attribute to 10.7 million deaths globally.Different clinical and population-wide strategies have been in use to reduce high blood pressure such as to slow the rise of obesity, to increase physical activity, to reduce tobacco use and to change dietary patterns including the reduction of salt intake.However, better knowledge of the effects of high blood pressure on human metabolism is needed to provide insight into the molecular mechanisms by which blood pressure is controlled. The human metabolic phenotype reflects the health status of an individual and is affected by genetic, environmental, dietary and gut-microbial variation.I propose to use a metabolic phenotyping approach to discover biochemical compounds (metabolites) in urine related to blood pressure and associated dietary patterns, and to investigate how these potential clinical metabolic targets fit in the biochemical processes involved with the onset of high blood pressure and homeostatic regulation of blood pressure.