Identification of Metabolic Phenotypes and Systemic Biochemical Reaction Networks Associated with Human Blood Pressure

与人体血压相关的代谢表型和全身生化反应网络的鉴定

• 批准号: MR/S004033/1
• 负责人: Joram Posma
• 金额: $ 42.24万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS004033%2F1
• 关键词: Identification; Metabolic; Phenotypes; Systemic; Biochemical

High blood pressure is an important component of metabolic syndrome and one of the most common modifiable risk factors for human cardiovascular disease and non-communicable disease. High blood pressure remains to be the leading cause for global disease burden and is estimated to attribute to 10.7 million deaths globally.Different clinical and population-wide strategies have been in use to reduce high blood pressure such as to slow the rise of obesity, to increase physical activity, to reduce tobacco use and to change dietary patterns including the reduction of salt intake.However, better knowledge of the effects of high blood pressure on human metabolism is needed to provide insight into the molecular mechanisms by which blood pressure is controlled. The human metabolic phenotype reflects the health status of an individual and is affected by genetic, environmental, dietary and gut-microbial variation.I propose to use a metabolic phenotyping approach to discover biochemical compounds (metabolites) in urine related to blood pressure and associated dietary patterns, and to investigate how these potential clinical metabolic targets fit in the biochemical processes involved with the onset of high blood pressure and homeostatic regulation of blood pressure.

高血压是代谢综合征的重要组成部分，也是人类心血管疾病和非传染性疾病最常见的可改变的危险因素之一。高血压仍然是全球疾病负担的主要原因，据估计，全球有1070万人死于高血压。不同的临床和全人群策略被用于降低高血压，如减缓肥胖的上升，增加体力活动，减少烟草使用，以及改变饮食模式，包括减少盐的摄入。然而，需要更好地了解高血压对人类新陈代谢的影响，以深入了解控制血压的分子机制。人类的代谢表型反映了个体的健康状况，并受到遗传、环境、饮食和肠道微生物变化的影响。我建议使用代谢表型分析方法来发现尿液中与血压和相关饮食模式相关的生化化合物(代谢物)，并研究这些潜在的临床代谢指标如何适应与高血压发病和血压稳态调节相关的生化过程。

项目成果

Additional file 1 of Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

肿瘤微生物群中的 Pathobionts 的附加文件 1 可预测结直肠癌切除后的生存率

• DOI: 10.6084/m9.figshare.22790342
• 发表时间: 2023
• 作者: Alexander J

Auto-CORPus: A Natural Language Processing Tool for Standardizing and Reusing Biomedical Literature.

• DOI: 10.3389/fdgth.2022.788124
• 发表时间: 2022
• 期刊: Frontiers in digital health
• 作者: Beck T;Shorter T;Hu Y;Li Z;Sun S;Popovici CM;McQuibban NAR;Makraduli F;Yeung CS;Rowlands T;Posma JM
• 通讯作者: Posma JM

Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial.

• DOI: 10.1093/ajcn/nqab211
• 发表时间: 2022-11
• 期刊: The American journal of clinical nutrition

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer.

• DOI: 10.1186/s40168-023-01518-w
• 发表时间: 2023-05-08
• 期刊: MICROBIOME
• 影响因子: 15.5
• 作者: Alexander, James L.;Posma, Joram M.;Scott, Alasdair;Poynter, Liam;Mason, Sam E.;Doria, M. Luisa;Herendi, Lili;Roberts, Lauren;McDonald, Julie A. K.;Cameron, Simon;Hughes, David J.;Liska, Vaclav;Susova, Simona;Soucek, Pavel;Der Sluis, Verena Horneffer-van;Gomez-Romero, Maria;Lewis, Matthew R.;Hoyles, Lesley;Woolston, Andrew;Cunningham, David;Darzi, Ara;Gerlinger, Marco;Goldin, Robert;Takats, Zoltan;Marchesi, Julian R.;Teare, Julian;Kinross, James
• 通讯作者: Kinross, James

Blood pressure interactions with the DASH dietary pattern, sodium, and potassium: The International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP).

• DOI: 10.1093/ajcn/nqac067
• 发表时间: 2022-07-06
• 期刊: The American journal of clinical nutrition