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MOLECULAR REGULATION: EMBYROGENESIS BY METABOLIC STRESS

MOLECULAR REGULATION: EMBYROGENESIS BY METABOLIC STRESS
分子调控:代谢应激的胚胎发生
批准号:
6190733
负责人:
MARY R LOEKEN
金额:
$24.31万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-01 至 2004-08-31

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中文摘要
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英文摘要
DESCRIPTION: (Adapted from the Investigator's Abstract): Aim 1 will 1 examine whether Pax-3 and genes that are regulated by oxidative or hypoxic stress compete for transcription factor binding and transcription regulation. Aim 2 will examine whether the adapter factor, p300/CBP, which regulates oxidative and hypoxia-responsive genes, participates in the regulation of Pax-3. Aim 3 will test whether overexpression of factors that regulate both developmental control and stress-responsive genes protects embryos from the altered gene expression, apoptosis, and NTD associated with excess glucose.
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Role of Slc2a2/Glut2 in Embryo and Stem Cell Metabolism, Self-Renewal, and Pathways Involved in Diabetic Embryopathy
  • 批准号:
    8913593
  • 项目类别:
  • 资助金额:
    $53.31万
  • 财政年份:
    2015
  • 负责人:
    MARY R LOEKEN
  • 依托单位:
Embryonic Gene Expression During Diabetic Embryopathy
  • 批准号:
    8004610
  • 项目类别:
  • 资助金额:
    $10.53万
  • 财政年份:
    2009
  • 负责人:
    MARY R LOEKEN
  • 依托单位:
EFFECT OF HYPERGLYCEMIA ON NEURALATING MOUSE EMBRYOS
  • 批准号:
    7953823
  • 项目类别:
  • 资助金额:
    $0.56万
  • 财政年份:
    2008
  • 负责人:
    MARY R LOEKEN
  • 依托单位:
EFFECT OF HYPERGLYCEMIA ON NEURALATING MOUSE EMBRYOS
  • 批准号:
    6979993
  • 项目类别:
  • 资助金额:
    $0.38万
  • 财政年份:
    2003
  • 负责人:
    MARY R LOEKEN
  • 依托单位:
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