MOLECULAR REGULATION: EMBYROGENESIS BY METABOLIC STRESS

分子调控：代谢应激的胚胎发生

• 批准号: 6643452
• 负责人: MARY R LOEKEN
• 金额: $ 24.98万
• 依托单位: JOSLIN DIABETES CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643452
• 关键词: apoptosis; binding proteins; embryogenesis; gene expression; genetic regulation; genetically modified animals; glucose; laboratory mouse; neural plate /tube; oxidative stress; tissue /cell culture; transcription factor

DESCRIPTION: (Adapted from the Investigator's Abstract): Aim 1 will 1 examine whether Pax-3 and genes that are regulated by oxidative or hypoxic stress compete for transcription factor binding and transcription regulation. Aim 2 will examine whether the adapter factor, p300/CBP, which regulates oxidative and hypoxia-responsive genes, participates in the regulation of Pax-3. Aim 3 will test whether overexpression of factors that regulate both developmental control and stress-responsive genes protects embryos from the altered gene expression, apoptosis, and NTD associated with excess glucose.

描述：（改编自研究者摘要）：目标1将检查 Pax-3和受氧化或缺氧应激调控的基因 竞争转录因子结合和转录调节。目的2 将研究是否衔接因子，p300/CBP，调节氧化 和缺氧反应基因，参与Pax-3的调节。目标3 将测试是否过度表达调节发育和生长的因子， 控制基因和应激反应基因保护胚胎不受基因改变的影响 表达、凋亡和与过量葡萄糖相关的NTD。