Development of dynamin inhibitors as novel therapies for epilepsy

动力抑制剂作为癫痫新疗法的开发

• 批准号: nhmrc : 571076
• 负责人: Prof Adam Mccluskey
• 金额: $ 60.24万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-dynamin-inhibitors-therapies-epilepsy/99030
• 关键词: Development; dynamin; inhibitors; novel; therapies

Epilepsy affects 1% of people, but 30% do not respond to current anti-epileptic drugs (AEDs). Traditional drug discovery has not improved this situation. Our team discovered two exciting new targets for design of better AEDs. One of them blocks seizure in animals. Our aim is to determine how well they work in true animal models of epilepsy. If successful, this will accelerate development of new AEDs with less side-effects, benefiting large sectors of the Australian community.

1%的人患有癫痫，但30%的人对目前的抗癫痫药物（aed）没有反应。传统的药物发现并没有改善这种情况。我们的团队发现了两个令人兴奋的新目标，用于设计更好的aed。其中一种能阻止动物癫痫发作。我们的目标是确定它们在真正的癫痫动物模型中的效果。如果成功，这将加速副作用更小的新型aed的开发，使澳大利亚社会的大部分人受益。