Development of Small Molecule Isoform-Selective Dynamin Inhibitors

小分子异构体选择性动力抑制剂的开发

• 批准号: nhmrc : 571248
• 负责人: Ms Anna Mariana
• 金额: $ 5.7万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-small-molecule-dynamin-inhibitors/116186
• 关键词: Development; Small; Molecule; Isoform; Selective

Dynamin has roles in nerve cell communication and in cell division. There are 3 dynamin genes: dynamin I in brain; dynamin II in all cells; and dynamin III in brain and testes. Determination of potential selectivity of small molecule dynamin inhibitors for each dynamin gene can provide a basis for the development of new antiepileptic drugs which are specific for dynamin I and thus neuronal tissues, as well as new anticancer drugs that target dynamin II in nonneuronal cells.

发动蛋白在神经细胞通讯和细胞分裂中起作用。有3种动力蛋白基因：大脑中的动力蛋白I;所有细胞中的动力蛋白II;大脑和睾丸中的动力蛋白III。确定小分子发动蛋白抑制剂对每个发动蛋白基因的潜在选择性可以为开发针对发动蛋白I和神经元组织的新型抗癫痫药物以及针对非神经元细胞中发动蛋白II的新型抗癌药物提供基础。