Force in Migration: The mechanism of Nuclear Force Coupling driven invasive cell migration

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Cell migration is fundamental for many processes in the human body and its deregulation can lead to a vast variety of pathologies including cancer cell invasion and impaired cell locomotion in prematurely ageing cells. Cells in tissues need to sense the physical qualities -for example the stiffness or flexibility- of their environment and they can adapt their behaviour and shape accordingly. This proposal aims to investigate just how cells effectively transmit signals caused by physical cues on their outside directly to their nucleus to enable cell migration and changes in gene transcription. This will help to understand how forces applied to the nucleus can drive cancer cell invasion into surrounding tissues.