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MECHANICAL PROPERTIES OF RODENT BONES

啮齿动物骨骼的机械特性

基本信息

批准号：
6159006
负责人：
Guigen Zhang
金额：
$ 9.94万
依托单位：
GZ TECHNOLOGIES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-09-15 至 2001-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6159006
关键词：
Rodentias bioengineering /biomedical engineering biomechanics biomedical equipment development blood viscosity bone computer system design /evaluation mechanical pressure mechanical stress skeletal stress surface property

项目摘要

The project is to develop a miniature, multifunctional, high precision, low-cost, and easy-to-use machine for measuring mechanical properties and other stress or strain markers of rodent bones in order to evaluate the biomechanical impact of various medical compounds on bone failure prevention in the battle against osteoporosis. The multifunctional features of this machine will allow mechanical tests on rodent bones using single-dimensional and multi-dimensional states of static and cyclic loads, and nano/micro adhesion and indentation tests on cells, engineered tissues, and surface coatings. This machine is computer driven and controlled, and the entire system uses a closed loop structure with feedback control allowing load-control or stroke-control testing mode selection. The entire system will also allow precise determination of mechanical environment including stress and strain, displacement-to- failure, strength, modulus, visoelastic properties, hysteresis, creep displacement, micro-hardness, local surface stiffness, and surface adhesion properties. Based on the success in Phase I effort, this project will refine the machine, expand its versatility, and finalize the product. Upon completion of this project, commercial-ready machines will be derived.

本项目旨在研制一种微型、多功能、高精度、低成本，易于使用的机器，用于测量机械性能，啮齿动物骨骼的其他应力或应变标记物，以评估各种药物对骨衰竭的生物力学影响预防骨质疏松症。多功能这台机器的特点将允许对啮齿动物骨骼进行机械测试，静态和循环的单维和多维状态负载和纳米/微米粘附力以及对细胞的压痕测试，组织和表面涂层。这台机器是电脑驱动的，整个系统采用闭环结构，允许负载控制或行程控制测试模式的反馈控制选择.整个系统还将允许精确确定力学环境，包括应力和应变，位移，破坏，强度，模量，粘弹性，滞后，蠕变位移、显微硬度、局部表面刚度和表面粘合性能基于第一阶段工作的成功，该项目将改进机器，扩大其多功能性，并最终确定产品。该项目完成后，商业就绪的机器将推导