Multi-scale Computational Modeling Core

多尺度计算建模核心

• 批准号: 10244916
• 负责人: Guigen Zhang
• 金额: $ 33.88万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244916
• 关键词: Address; Area; Biomedical Engineering; Caring; Centers of Research Excellence; Code; Complex; Computer Models; Computer Simulation; Computer software; Country; Coupled; Custom; Data; Data Security; Data Storage and Retrieval; Development; Devices; Diagnosis; Differential Equation; Directories; Discipline; Educational workshop; Engineering; Ensure; Finite Element Analysis; Generations; Goals; Health; Health system; High Performance Computing; Human body; Information Technology; Infrastructure; Institution; Intervention; Knowledge; Laboratory Research; Laws; Location; Maintenance; Mechanics; Mentors; Methods; Mission; Modeling; Musculoskeletal; Musculoskeletal System; Outcome; Patients; Policies; Population; Preventive; Research; Research Personnel; Resolution; Resources; Role; Running; Services; Software Tools; South Carolina; Specimen; Statistical Models; Strategic Planning; Supercomputing; Technology; Therapeutic; Thermodynamics; Tissues; Training; Translational Research; United States; Universities; Visualization; base; computerized tools; cyber infrastructure; data access; data handling; experience; human model; imaging Segmentation; improved; materials science; model building; molecular dynamics; multi-scale modeling; multidisciplinary; parallel computer; personalized care; tool; virtual human

SUMMARY The Multi-scale Computational Modeling (MCM) Core will provide support for SC-TRIMH investigators toward building a patient-specific and precision-care musculoskeletal system through multi-scale modeling at cellular, tissue, body levels. Specifically, we will (Aim 1) acquire and maintain the most advanced software tools and packages to enable SC-TRIHM investigators to perform computational bioengineering modeling at cellular, tissue, and body multi-scale levels; (Aim 2) tune and customize the set of computational tools and packages so that the SC-TRIMH investigators can take full advantage of Clemson's Palmetto Cluster to meet their computational needs; (Aim 3) provide general and project-specific assistances and mentoring to all SC-TRIMH investigators and their associates, especially those who do not have primary expertise in modeling of complex problems, with training sessions, workshops and one-on-one hands-on experiences; and (Aim 4) promote the MCM Core as a leading resource and the “go-to place” for researchers from Clemson University, the southeast region, FDA and beyond in multi-scale and multi-discipline computational modeling. To do this we will take full advantage of, and expand the current resources and capabilities of the resources at Clemson University, which entails Clemson's powerful supercomputing capability – the “Palmetto Cluster” (ranked in the Top 4 among public institutions in the United States), the Multiphysics Modeling Studio, and the large amounts of patient/specimen specific data needed for model building at Greenville Health Systems. One major challenge facing the field of bioengineering is its heavy reliance on the knowledge and investigative approaches developed in traditional compartmentalized disciplines such as mechanical engineering, materials science, etc. Most of the bioengineering problems are complex and cannot be easily reduced to sub-problems belonging to separated disciplines. Bioengineering based on computational modeling offers a unique way to address this challenge. The MCM Core will strive to provide all necessary support, mentoring and training to SC-TRIMH investigators by employing our extensive existing capabilities and expertise, as well as further developing them. Depending on the specific needs of these projects, the services and support will vary from hands-on and technically oriented modeling assistance, to helping access and utilize the Palmetto Cluster capability to maximal research benefit. Additionally, the core will provide mentoring and strategic planning to all investigators, especially those who do not have primary expertise in modeling of complex problems. Aside from building the MCM Core as a unique resource that will provide essential expertise and infrastructure in the area of multi-scale and multi-discipline computational modeling of bioengineering problems to support the SC-TRIMH investigators, we aim to develop this multi-scale computational modeling core into the `go-to' place for researchers from across region, and around the country and the world for complex computational bioengineering needs.

总结 多尺度计算建模（MCM）核心将为SC-TRIMH研究人员提供支持， 通过在细胞上的多尺度建模来构建患者特异性和精确护理的肌肉骨骼系统， 组织和身体水平具体而言，我们将（目标1）获得和维护最先进的软件工具， 软件包，使SC-TRIHM研究人员能够在细胞， 组织和身体多尺度水平;（目标2）调整和定制计算工具和软件包的集合， SC-TRIMH研究人员可以充分利用克莱姆森的棕榈集群，以满足他们的 计算需求;（目标3）为所有SC-TRIMH提供一般和项目特定的帮助和指导 研究人员及其同事，特别是那些没有复杂建模的主要专业知识的人， 通过培训班、讲习班和一对一的实践经验，解决问题;以及（目标4）促进 MCM Core是东南部克莱姆森大学研究人员的领先资源和“首选之地” 区域、FDA及其他领域的多尺度和多学科计算建模。为此，我们将充分 优势，并扩大现有的资源和能力的资源在克莱姆森大学，这 这需要克莱姆森强大的超级计算能力-“棕榈集群”（在公众中排名前4位 多物理建模工作室（Multiphysics Modeling Studio），以及大量的患者/标本。 格林维尔卫生系统建立模型所需的具体数据。该领域面临的一个主要挑战是， 生物工程是其严重依赖的知识和研究方法，发展在传统的 划分学科，如机械工程，材料科学等。 生物工程问题是复杂的，不能简单地归结为属于分离的子问题。 学科基于计算建模的生物工程为解决这一挑战提供了独特的方法。的 MCM Core将努力通过以下方式为SC-TRIMH调查人员提供所有必要的支持、指导和培训： 利用我们广泛的现有能力和专业知识，并进一步发展它们。取决于 这些项目的具体需求，服务和支持将有所不同，从动手和技术导向 建模援助，以帮助访问和利用棕榈集群的能力，以最大限度地提高研究效益。 此外，核心小组还将为所有调查人员，特别是那些从事调查工作的人提供指导和战略规划。 在复杂问题的建模方面没有主要的专业知识。除了将MCM Core打造成一个独特的 资源，将提供必要的专业知识和基础设施领域的多规模和多学科 生物工程问题的计算建模，以支持SC-TRIMH研究人员，我们的目标是开发 这种多尺度计算建模核心成为跨区域和周围研究人员的“去”的地方， 国家和世界的复杂计算生物工程的需要。