CORE--METHODOLOGY AND DATA MANAGEMENT

方法和数据管理核心至关重要 该MAMDC及其EEHSR组件的成功， 特别的。集中提供数据库方面的专门知识， 研究表格的构建;数据录入、监测和检索，以及 用于测试假设和控制的各种分析技术 潜在的混杂因素是所有研究者的基本资源。 的 核心组织协助教育工作者、流行病学家和卫生服务部门 来自多个部门和部门的研究人员在研究广泛的 各种疾病和人口统计学群体，包括系统性狼疮 红斑，骨关节炎，幼年皮肌炎（JDMS）， 类风湿性关节炎和老年人。 核心资源已经使用 由于规模经济， 与EEHSR组件的协调。 认识到更新 分析技术已经变得可用并且更被接受， 这一提议代表了我们在临床领域工作的扩展， 流行病学和卫生服务研究，这一拟议的核心是两个 更大，以支持更大的工作量和更广泛的使用这些 新的分析技术。由于执行委员会的 决定强调纵向和成本效益研究， 高级统计技术专家（广义估计 方程（GEE），分类和回归树（CART）， 控制选择偏差的计量经济学方法，荟萃分析）， 经济学和决策分析（随机树模型，连续- 风险效用评估）被招募为核心共同研究者。 临床流行病学也已正式纳入核心 结构 核心将支持四个EEHSR提案， 赠款申请和JDMS登记处的资助活动， 儿童纪念医院 它将继续促进 MAMDC研究环境，提供数据管理和 为从事关节炎相关研究的研究者提供方法学帮助 research. 举办EEHSR/Core研究会议， 加强对卫生服务研究的可行性和支持， 西北大学的芝加哥校区将进一步提高 核心对环境的影响。

The Methodology and Data Management Core is critically important to the success of this MAMDC and its EEHSR Component in particular. The centralized availability of expertise in database and study form construction; data entry, monitoring, and retrieval, and the various analytic techniques used to test hypotheses and control for potential confounders are essential resources for all investigators. The Core has assisted educators, epidemiologists, and health services researchers from several divisions and departments in studying a wide variety of disease and demographic groups including systemic lupus erythematosus, osteoarthritis, juvenile dermatomyositis (JDMS), rheumatoid arthritis, and the elderly. Core resources have been used efficiently because of the economies of scale in addition to excellent coordination with the EEHSR component. Recognizing that newer analytic techniques have become available and more accepted and that this proposal represents an expansion of our work in clinical epidemiology and health services research, this proposed Core is both larger to support a greater volume of work and broader t utilize these new analytic techniques. As a result of the Executive Committee's decision to emphasize longitudinal and cost-effectiveness research, experts in advanced statistical techniques (generalized estimating equation (GEE), classification and regression trees (CART), econometric approaches to controlling selection bias, meta-analysis), economics, and decision analysis (stochastic tree modeling, continuous- risk utility assessment) have been recruited as Core co-investigators. Clinical Epidemiology has also been formally included within the Core structure. The Core will support the four EEHSR proposals in this grant application and the funded activities of the JDMS registry and Children's Memorial Hospital. It will continue to contribute to the MAMDC research environment by providing data management and methodologic assistance to investigators who engage in arthritis related research. The institution of a EEHSR/Core research conference and enhanced viability and support for health services research on Northwestern University's Chicago Campus will further heighten the Core's influence on the environment.