Methodology Core

方法/数据管理核心对西北大学的成功至关重要 MCRC大学集中提供数据库和研究表格编制方面的专门知识;数据 监测、数据输入和检索;以及用于检验假设和控制的各种分析技术。 潜在的混杂因素是现有和新的研究者的基本资源。吴文正 更新的分析技术已经变得可用，并且在医学文献中更被接受， 建议继续扩展我们在临床流行病学和卫生服务研究方面的工作 以前实施的。鉴于该中心对纵向研究的重视，高级专家 统计技术[广义估计方程（GEE），离散生存时间回归分析， 以及荟萃分析和分类与回归树（CART）]、经济学、决策分析、临床 流行病学、行为科学和基因组学被列为核心研究者。新的专业知识， 患者报告的结果测量、饮食/体力活动测量和生物信息学现在包括在内。 核心为所有3个提议的项目提供基本的方法、数据完整性和安全计划功能。 MCRC项目。此外，这一核心将继续更广泛地服务于关节炎研究界 通过提供鼓励核心方法学家和工作人员之间合作的环境， MCRC附属教师和学员在每一个临床，流行病学和卫生服务关节炎研究 该项目已在西北大学提出并实施。通过与西北大学的积极关系， 范伯格大学医学院（NU-FSM）预防医学系，物理医学系 与康复，医学社会科学，医疗保健研究所，和NU临床和 转化科学（NUCATS）研究所，MCRC方法/数据管理核心能够绘制 对相关人才和专业知识的多元化大学社区，不仅有助于解决研究 与NIAMS感兴趣的各种流变学条件有关的项目的挑战（例如， 骨关节炎、类风湿性关节炎、系统性红斑狼疮、硬皮病），而且还促进和 支持这些领域的跨学科团队研究。核心由一位经验丰富的流变学专家领导 调查员，包括高级和初级教师方法学家以及经验丰富的统计 分析师和程序员/数据库管理员。多年来，西北大学的NIAMS P60，核心 业务程序已经发展到最大限度地提高教育的成本效益和质量。

The Methodology/Data Management Core is critically important to the success of the Northwestern University MCRC. The centralized availability of expertise in database and study form development; data monitoring, data entry and retrieval; and the various analytic techniques used to test hypotheses and control for potential confounders are essential resources for both established and new investigators. Recogniz ng that newer analytic techniques have become available and more accepted in the medical literature, this proposal continues the expansion of our work in clinical epidemiology and health services research previously implemented. Given this Center's emphasis on longitudinal research, experts in advanced statistical techniques [generalized estimating equations (GEE), discrete survival time regression analysis, as well as meta-analysis and classification and regression trees (CART)], economics, decision analysis, clinical epidemiology, behavioral science, and genomics are included as Core investigators. New expertise in patient reported outcome measures, diet/physical activity measurement, and bioinformatics is now included. The Core provides essential methodological, data integrity, and safety plan functions for all 3 proposed MCRC projects. In addition, this Core will continue to serve the arthritis research community more broadly by providing an environment that encourages collaboration between Core methodologists and staff and MCRC-affiliated faculty and trainees on every clinical, epidemiologic, and health services arthritis reseai'ch project proposed and implemented at Northwestern. Through its active relationships with the Northwestern University Feinberg School of Medicine's (NU-FSM) Departments of Preventive Medicine, Physical Medicine & Rehabilitation, and Medical Social Sciences, the Institute for Healthcare Studies, and the NU Clinical and Translational Science (NUCATS) Institute, the MCRC Methodology/Data Management Core is able to draw on the relevant talent and expertise of a diverse University community to not only help solve the research challenges of projects pertaining to a variety of rheumatologic conditions of interest to NIAMS (e.g., osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, scleroderma), but also to promote and sustain interdisciplinary team research in these fields. The Core is led by a seasoned rheumatology investigator and includes both senior and junior faculty methodologists as well as experienced statistical analysts and programmers/database managers. Over the years of Northwestern's NIAMS P60, Core operational procedures have evolved to maximize cost-effectiveness and quality of educational offerings.