Methodology Core

方法和数据管理核心对于 西北大学MAMDC和目前的MCRC，这是至关重要的更新。的 集中提供数据库和研究表格构建方面的专业知识;数据录入、监测和 检索;以及用于检验假设和控制潜在混杂因素的各种分析技术 是已设调查员和新调查员的基本资源。核心组织协助教育工作者， 流行病学家和来自几个部门和部门的卫生服务研究人员在研究一个广泛的 各种疾病和人口统计学群体，包括系统性红斑狼疮、骨关节炎、青少年 皮肌炎（JDMS）、类风湿性关节炎和老年人。核心资源得到有效利用 因为规模经济。 认识到更新的分析技术已经成为可用的，并在医学领域得到更广泛的接受， 文献，这项建议继续扩大我们的工作，在临床流行病学和卫生服务 以前的研究。鉴于该中心对纵向结果研究的重视，专家们 在高级统计技术（广义估计方程（GEE），分类和回归 树（CART），离散考克斯回归分析，荟萃分析），经济学，决策分析，临床 流行病学、行为科学和遗传学被列为核心研究者。核心将支持 本拨款申请书内的三份完整建议书及一份发展/可行性建议书，以及 资助的活动。它将继续通过提供数据为MCRC的研究环境做出贡献 为从事关节炎相关研究的研究者提供管理和方法学方面的帮助。的 核心研究者参与关节炎临床研究会议，提高生存能力， 支持临床流行病学、卫生服务研究、行为科学和遗传学， 西北大学的芝加哥校区进一步提高了核心对环境的影响。

The Methodology and Data Management Core has been critically important to the success of the Northwestern University MAMDC and the current MCRC and is critically important to this renewal. The centralized availability of expertise in database and study form construction; data entry, monitoring, and retrieval; and the various analytic techniques used to test hypotheses and control for potential confounders are essential resources for both established and new investigators. The Core has assisted educators, epidemiologists, and health services researchers from several divisions and departments in studying a wide variety of disease and demographic groups including systemic lupus erythematosus, osteoarthritis, juvenile dermatomyositis (JDMS), rheumatoid arthritis, and the elderly. Core resources have been used efficiently because of the economies of scale. Recognizing that newer analytic techniques have become available and more accepted in the medical literature, this proposal continues the expansion of our work in clinical epidemiology and health services research previously implemented. Given this Center's emphasis on longitudinal outcomes research, experts in advanced statistical techniques (generalized estimating equations (GEE), classification and regression trees (CART), discrete Cox regression analysis, meta-analysis), economics, decision analysis, clinical epidemiology , behavioral science and genetics are included as Core investigators. The Core will support the three full proposals and the one developmental/feasibility proposal in this grant application and the funded activities. It will continue to contribute to the MCRC research environment by providing data management and methodologic assistance to investigators who engage in arthritis related research. The participation of Core investigators in the arthritis clinical research conference and enhanced viability and support for clinical epidemiology, health services research, behavioral science, and genetics on Northwestern University's Chicago Campus further heighten the Core's influence on the environment.