INDUCTION OF CELLULAR IMMUNITY AGAINST GAG AND NET BY ORAL VACCINE
INDUCTION OF CELLULAR IMMUNITY AGAINST GAG AND NET BY ORAL VACCINE
批准号:
6100234
负责人:
David Michael Hone
金额:
$9.44万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-05-15 至 2000-04-30
中文摘要
过去十年积累的证据加强了T
英文摘要
Evidence accumulated over the past decade has strengthened the case for T
cell-mediated mechanisms of protection against HIV. A major impediment to
the development of an HIV-1 vaccine that elicits such immunity, however,
has been the lack of a T cell-mediate response that correlates with
protection. For example, there is no definitive evidence correlating CTL
responses with protection against SIV or HIV. On the other hand, recent
evidence showing that chemokine-secreting T cells can suppress HIV-1
infection in vitro suggest a new mechanism of T cells can suppress HIV-1
infection in vitro, suggests a new mechanism of T cell-mediated
protection. Clearly, these studies justify continued investigation of the
means by which T cell-mediated responses can be induced by HIV-1 vaccines.
In this vein, the central hypothesis of this proposal is that a live oral
Salmonella-SIV vaccine vector will induce such responses in mice and non
human primates.
In the preliminary data section we present immunological data that
strengthen our central hypothesis. Thus, we showed that a single oral dose
of a Salmonella-HIV vector, bearing a secreted form of glycosylated gp120,
induced gp120-specific T cells that were predominated by IFN-gamma-
secreting CD4+ T cells and a strong gp120-specific mucosal response.
Furthermore, our data suggest that gp120-specific beta chemokine-secreting
responses develop in the mucosal compartment after oral immunization with
a Salmonella-HIV vaccine vector. Finally, we have shown that human-
specific attenuated Salmonella strain CVD 908 is well tolerated and
immunogenic in volunteers.
We now propose to extent these finding by constructing Salmonella vectors
that express chimeric SIV/MAC/239 Gag-Nef fusions and to characterize the
immunogenicity of these constructs for SIV-specific T cell responses in
mice. Further, the Salmonella-SIV construct that elicits the strongest
SIV-specific T cell responses in mice will be evaluated in an
immunogenicity and challenge trial in non-human primates. We believe that
this approach will provide fundamental information germane to the
development of an oral Salmonella-HIV-1 vaccine.
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会议论文
Development of a Bacteriophage Vaccine Vector System
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批准号:7659340
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项目类别:
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资助金额:$30.9万
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财政年份:2009
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负责人:David Michael Hone
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依托单位:
Improved Bladder Cancer Therapy With Recombinant BCG
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批准号:7326545
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资助金额:$25.39万
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财政年份:2007
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负责人:David Michael Hone
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依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:6867374
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项目类别:
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资助金额:$38.75万
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财政年份:2003
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负责人:David Michael Hone
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依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:7277571
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项目类别:
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资助金额:$23.05万
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财政年份:2003
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负责人:David Michael Hone
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依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:6699004
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项目类别:
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资助金额:$37.25万
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财政年份:2003
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负责人:David Michael Hone
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依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
-
批准号:7111595
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项目类别:
-
资助金额:$14.79万
-
财政年份:2003
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负责人:David Michael Hone
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依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:7768199
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项目类别:
-
资助金额:$25.04万
-
财政年份:2003
-
负责人:David Michael Hone
-
依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:6795297
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项目类别:
-
资助金额:$25.37万
-
财政年份:2003
-
负责人:David Michael Hone
-
依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:7186726
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项目类别:
-
资助金额:$56.26万
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财政年份:2003
-
负责人:David Michael Hone
-
依托单位:
Optimization of Salmonelle-HIV-1 DNA Vaccine Vectors
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批准号:6656103
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项目类别:
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资助金额:$11.33万
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财政年份:2003
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负责人:David Michael Hone
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依托单位:
SALMONELLA GP120 DNA VACCINE VECTOR
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批准号:6658272
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项目类别:
-
资助金额:$27.48万
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财政年份:2002
-
负责人:David Michael Hone
-
依托单位:
SALMONELLA GP120 DNA VACCINE VECTOR
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批准号:6502359
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项目类别:
-
资助金额:$27.48万
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财政年份:2001
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负责人:David Michael Hone
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依托单位:
Oral Vaccine-Induced Cellular Immunity Against HIV-1
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批准号:6408853
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项目类别:
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资助金额:$37.13万
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财政年份:2001
-
负责人:David Michael Hone
-
依托单位:
SALMONELLA GP120 DNA VACCINE VECTOR
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批准号:6349681
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项目类别:
-
资助金额:$27.48万
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财政年份:2000
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负责人:David Michael Hone
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依托单位:
IMMUNOGENICITY OF ORAL SIV & HIV1 VACCINES
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批准号:2887847
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项目类别:
-
资助金额:$28.18万
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财政年份:1998
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负责人:David Michael Hone
-
依托单位:
IMMUNOGENICITY OF ORAL SIV & HIV1 VACCINES
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批准号:6170784
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项目类别:
-
资助金额:$29.03万
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财政年份:1998
-
负责人:David Michael Hone
-
依托单位:
IMMUNOGENICITY OF ORAL SIV & HIV1 VACCINES
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批准号:2716234
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项目类别:
-
资助金额:$20.37万
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财政年份:1998
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负责人:David Michael Hone
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依托单位:
ORAL VACCINE INDUCED CELLULAR IMMUNITY AGAINST HIV1
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批准号:2428921
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项目类别:
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资助金额:$25.94万
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财政年份:1997
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负责人:David Michael Hone
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依托单位:
TARGETED DELIVERY OF MUSCOSAL HIV1 RNA VACCINE
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批准号:2673176
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项目类别:
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资助金额:$20.51万
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财政年份:1997
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负责人:David Michael Hone
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依托单位:
ORAL VACCINE INDUCED CELLULAR IMMUNITY AGAINST HIV1
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批准号:2673108
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项目类别:
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资助金额:$26.63万
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财政年份:1997
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负责人:David Michael Hone
-
依托单位:
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