MECHANISMS OF IMMUNOPATHOLOGY IN DHF/DSS

该计划项目的目标是了解免疫病理学 关于登革出血热(DHF)和登革休克综合征(DSS)， 登革热病毒感染的严重并发症。的频率 登革热病毒继发感染时DHF/DSS大得多 一种不同的登革热血清型菌株 原发感染。这些免疫病理结果已经放缓。 出于安全考虑，疫苗的开发。发病率和 与严重登革热感染相关的死亡率是一个主要的公众 健康问题，这种问题的频率正在增加。我们建议定义 与之相关的免疫病理学的分子和细胞基础 严重的登革热感染。

The goal of this program Project is to understand the immunopathology of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), the severe complications of dengue virus infections. The frequency of DHF/DSS is much greater during secondary infections with dengue virus strains of a different dengue serotype than that which caused the primary infection. These immunopathological results have slowed down vaccine development because of safety concerns. The morbidity and mortality associated with severe dengue infections is a major public health problem which is increasing in frequency. We propose to define the molecular and cellular basis of the immunopathology associated with severe dengue infections.