Cellular Immunity to Category A-C Viruses in Humans

人类对 A-C 类病毒的细胞免疫

• 批准号: 6702125
• 负责人: FRANCIS ANTHONY ENNIS
• 金额: $ 189.74万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6702125
• 关键词: bioterrorism /chemical warfare; cellular immunity; clinical research; microorganism immunology; virus

DESCRIPTION (provided by applicant): The proposed UMASS Center for Translational Research on Human Immunology and Biodefense is a comprehensive, interdepartmental collaboration to address, as its overall scientific theme, the role of human T lymphocyte responses in the immunopathogenesis of and protection from category A-C viral pathogens. The Center encompasses senior and junior investigators with significant prior expertise in human immunology and research on biodefense pathogens, including translation to clinical studies, and is organized around the following components: Project 1 (Poxviruses) will define immunodominant human T cell epitopes of vaccinia virus as markers of vaccine efficacy and advance knowledge toward the development of improved smallpox vaccines. Project 2 (Hantaviruses) will define human immune responses associated with immunopathogenesis of hemorrhagic fever with renal syndrome. Project 3 (Flaviviruses) will define protective and immunopathological cross-reactive human T cell responses to sequential virus infections. The Technical Development Component (TDC) will develop novel solid-phase array and proteomics technologies for application in T cell epitope identification, detection and enumeration of virus-specific T cells, and identification of biomarkers of protective or pathological T cell responses. Core facilities will provide flow cytometry, MHC class I production, MHC class II production, and program administration services for use by the research projects and TDC. A Pilot Projects component will support pilot funding of promising novel research concepts proposed by UMMS faculty. An Education component will support short-term training of non-Center investigators. The proposed Center will address important NIAID research priorities related to these biodefense pathogens as well as career development for young investigators. The Center will facilitate synergistic interactions between the various investigators, to be assessed by periodic internal and external review that will greatly enhance the overall research productivity.

描述（由申请人提供）：拟议的UMASS人类免疫学和生物防御转化研究中心是一个全面的跨部门合作，以解决其整体科学主题，人类T淋巴细胞反应在A-C类病毒病原体的免疫发病机制和保护中的作用。该中心包括高级和初级研究人员，他们在人类免疫学和生物防御病原体研究方面具有重要的专业知识，包括临床研究的翻译，并围绕以下组成部分组织：项目1（痘病毒）将定义牛痘病毒的免疫显性人类T细胞表位作为疫苗效力的标志物，并推动改进天花疫苗的发展。 项目2（汉坦病毒）将定义与肾综合征出血热免疫发病机制相关的人类免疫应答。 项目3（黄病毒）将定义对连续病毒感染的保护性和免疫病理学交叉反应性人类T细胞应答。 技术开发部门（TDC）将开发新型固相阵列和蛋白质组学技术，用于T细胞表位鉴定，病毒特异性T细胞的检测和计数，以及保护性或病理性T细胞反应的生物标志物的鉴定。 核心设施将提供流式细胞术，MHC I类生产，MHC II类生产和项目管理服务，供研究项目和TDC使用。 一个试点项目的组成部分将支持试点资金的有前途的新的研究概念提出的UMMS教师。教育部分将支持非中心研究者的短期培训。 拟议的中心将解决与这些生物防御病原体相关的重要NIAID研究优先事项以及年轻研究人员的职业发展。该中心将促进各种研究人员之间的协同互动，通过定期内部和外部审查进行评估，这将大大提高整体研究生产力。