Identifying Common Mechanisms of Neurodegeneration in Alzheimer's Disease, Amyotrophic lateral sclerosis and Parkinson's Disease

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This project is to support the initiation of a collaboration between the NEURONODE consortium, led by Dr. McCormick at Queen Mary University of London, and Dr. Finkbeiner's lab at the Gladstone Institute in San Francisco. Both groups propose to identify common mechanisms in neurodegenerative diseases. The collaboration with involved the exchange of models, methods, investigational tools, and expertise. This exchange will aid both groups in achieving their goals. We will expand our analysis to identify disease mechanisms involved neurodegeneration in AD and better understand if how the stress response of cells contribute to common pathogenic processes in the different diseases. They will provide critical information on how changes in protein translation may affect protein turnover in disease. Our joint studies will provide insights on the role of the cell degradation pathways and the cell trafficking pathways in neurodegenerative diseases.