An in silico structure-based approach to map the druggable allosteric space of membrane receptors

一种基于计算机结构的方法来绘制膜受体的可药物变构空间

• 批准号: BB/R006946/1
• 负责人: Peter Joseph McCormick
• 金额: $ 28.59万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR006946%2F1
• 关键词: silico; structure; based; approach; map

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization.

• DOI: 10.3390/biom11101503
• 发表时间: 2021-10-12
• 期刊: Biomolecules
• 影响因子: 5.5
• 作者: Joseph MD;Tomas Bort E;Grose RP;McCormick PJ;Simoncelli S
• 通讯作者: Simoncelli S

Understanding Probe Dependency of an Allosteric Site at the Dopamine D2 Receptor

了解多巴胺 D2 受体变构位点的探针依赖性

• DOI: 10.22541/au.167766532.26342619/v1
• 发表时间: 2023
• 作者: Gill A

Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction.

• DOI: 10.1021/acscentsci.1c00802
• 发表时间: 2021-11-24
• 期刊: ACS central science
• 影响因子: 18.2
• 作者: Ciancetta A;Gill AK;Ding T;Karlov DS;Chalhoub G;McCormick PJ;Tikhonova IG
• 通讯作者: Tikhonova IG