The impact of sleep on memory selectivity and problem solving: Common and distinct neural mechanisms

睡眠对记忆选择性和问题解决的影响：常见和独特的神经机制

• 批准号: 10389168
• 负责人: Kristin Sanders
• 金额: $ 6.76万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389168
• 关键词: Address; Adult; Affect; Age; Anxiety; Applications Grants; Area; Brain; Cognition; Cognitive; Cognitive deficits; Communication Research; Complex; Coupling; Cues; Detection; Development; Educational workshop; Electroencephalography; Emotional; Fellowship; Foundations; Future; Hour; Impairment; Knowledge; Laboratories; Learning; Link; Medical; Memory; Mental Depression; Mental disorders; Mentorship; Neurosciences; Participant; Personal Satisfaction; Persons; Polysomnography; Post-Traumatic Stress Disorders; Problem Solving; Process; Publications; REM Sleep; Research; Research Ethics; Research Personnel; Research Proposals; Rewards; Role; Sleep; Sleep Stages; Sleep disturbances; Solid; Specificity; Techniques; Testing; Time; Training; awake; career; clinical diagnosis; cognitive neuroscience; experience; experimental study; meetings; memory consolidation; memory process; neural correlate; neuromechanism; non rapid eye movement; novel; power analysis; relating to nervous system; skills; sleep spindle; sound; young adult

Sleep is important for cognitive well-being, yet many adults do not get enough sleep. Sleep is especially important for selectively strengthening memories that are emotionally salient, associated with rewards, and relevant for future use; and sleep’s effect on memory selectivity may exacerbate some mental disorders. However, the neural mechanisms of sleep-facilitated selectivity are still being identified, and whether the same mechanisms generalize across different cognitive domains such as emotional memory and problem solving is unknown. The current research will examine 1) the interaction and unique contribution of sleep to emotional memory selectivity and problem solving; 2) the neural signatures of sleep’s effect on selectivity; and 3) whether targeted memory reactivation during rapid eye movement sleep similarly facilitates emotional memory selectivity and problem solving. We will record participants’ brain activity using EEG while they sleep in one of four state-of-the-art laboratory bedrooms, allowing us to precisely identify participants’ sleep stages and associated neural signatures. This research will lead to a better understanding of the neural mechanisms of sleep’s effect on cognition, allowing future research to examine the effect of sleep disruption on sleep-facilitated selectivity. The fellowship training plan will enable the applicant to conduct the proposed research and prepare her for a future career as an independent researcher. Through coursework, workshops, and mentorship, the applicant will extend her prior training in problem solving to include expertise in the cognitive neuroscience of sleep and memory, including EEG analysis techniques such as spectral power analysis, sleep spindle detection, and slow- oscillation-spindle coupling. In addition, the training plan provides extensive professional development in areas of academic communication, research management, and research ethics. Results from the proposed research will be widely disseminated in scientific meetings and publications, and will inform novel research questions at the intersection of sleep, memory, and problem solving, providing a solid foundation from which the applicant can launch her independent research career.

睡眠对于认知健康很重要，但许多成年人睡眠不足。睡眠是 对于有选择地强化情感上突出的记忆尤其重要， 与奖励相关，并与未来使用相关；以及睡眠对记忆选择性的影响 可能会加剧一些精神障碍。然而，促进睡眠的神经机制 选择性仍在确定中，以及相同的机制是否可以普遍适用 不同的认知领域，例如情绪记忆和问题解决能力是未知的。这 当前的研究将探讨 1) 睡眠对情绪的相互作用和独特贡献 记忆选择性和问题解决； 2）睡眠对选择性影响的神经特征； 3) 快速眼动睡眠期间的目标记忆重新激活是否类似 促进情绪记忆选择性和问题解决。我们将记录参与者的大脑 当他们在四个最先进的实验室卧室之一睡觉时使用脑电图进行活动，允许 我们可以准确识别参与者的睡眠阶段和相关的神经特征。这 研究将有助于更好地理解睡眠影响的神经机制 认知，使未来的研究能够检验睡眠中断对促进睡眠的影响 选择性。奖学金培训计划将使申请人能够进行拟议的 研究并为她未来作为独立研究员的职业生涯做好准备。通过 课程作业、研讨会和指导，申请人将扩展她之前的问题培训 解决睡眠和记忆认知神经科学方面的专业知识，包括脑电图 分析技术，例如频谱功率分析、睡眠纺锤波检测和慢速分析 振荡主轴耦合。此外，培训计划还提供广泛的专业知识 学术交流、研究管理和研究伦理领域的发展。 拟议研究的结果将在科学会议和 出版物，并将提供睡眠、记忆和睡眠交叉点的新研究问题 解决问题，为申请人启动她的工作提供坚实的基础 独立的研究生涯。