The impact of sleep on memory selectivity and problem solving: Common and distinct neural mechanisms

睡眠对认知健康很重要，但许多成年人睡眠不足。睡眠是 对于选择性地强化情感上突出的记忆尤其重要， 与奖励相关，与未来使用相关;以及睡眠对记忆选择性的影响 可能会加重某些精神障碍然而，睡眠促进的神经机制 选择性仍在确定中，以及相同的机制是否适用于 不同的认知领域，如情感记忆和解决问题是未知的。的 目前的研究将研究1）睡眠对情绪的相互作用和独特贡献， 2）睡眠对记忆选择性的影响; 以及3）在快速眼动睡眠期间目标记忆再激活是否类似于 促进情绪记忆的选择性和解决问题。我们将记录参与者的大脑 当他们在四个最先进的实验室卧室之一睡觉时，使用EEG进行活动， 我们可以精确地识别参与者的睡眠阶段和相关的神经信号。这 研究将有助于更好地理解睡眠对大脑神经系统的影响。 认知，允许未来的研究来检查睡眠中断对睡眠促进的影响。 选择性研究金培训计划将使申请人能够开展拟议的 研究和准备她未来的职业生涯作为一个独立的研究员。通过 课程，研讨会和导师，申请人将延长她以前的培训问题 解决包括睡眠和记忆的认知神经科学的专业知识，包括EEG 分析技术，如频谱功率分析，睡眠纺锤波检测，和慢- 振动-主轴耦合此外，培训计划提供了广泛的专业知识， 在学术交流，研究管理和研究伦理领域的发展。 拟议研究的结果将在科学会议上广泛传播， 出版物，并将告知新的研究问题，在睡眠，记忆， 解决问题，提供一个坚实的基础，从申请人可以推出她 独立的研究生涯。

Sleep is important for cognitive well-being, yet many adults do not get enough sleep. Sleep is especially important for selectively strengthening memories that are emotionally salient, associated with rewards, and relevant for future use; and sleep’s effect on memory selectivity may exacerbate some mental disorders. However, the neural mechanisms of sleep-facilitated selectivity are still being identified, and whether the same mechanisms generalize across different cognitive domains such as emotional memory and problem solving is unknown. The current research will examine 1) the interaction and unique contribution of sleep to emotional memory selectivity and problem solving; 2) the neural signatures of sleep’s effect on selectivity; and 3) whether targeted memory reactivation during rapid eye movement sleep similarly facilitates emotional memory selectivity and problem solving. We will record participants’ brain activity using EEG while they sleep in one of four state-of-the-art laboratory bedrooms, allowing us to precisely identify participants’ sleep stages and associated neural signatures. This research will lead to a better understanding of the neural mechanisms of sleep’s effect on cognition, allowing future research to examine the effect of sleep disruption on sleep-facilitated selectivity. The fellowship training plan will enable the applicant to conduct the proposed research and prepare her for a future career as an independent researcher. Through coursework, workshops, and mentorship, the applicant will extend her prior training in problem solving to include expertise in the cognitive neuroscience of sleep and memory, including EEG analysis techniques such as spectral power analysis, sleep spindle detection, and slow- oscillation-spindle coupling. In addition, the training plan provides extensive professional development in areas of academic communication, research management, and research ethics. Results from the proposed research will be widely disseminated in scientific meetings and publications, and will inform novel research questions at the intersection of sleep, memory, and problem solving, providing a solid foundation from which the applicant can launch her independent research career.