PARASITIC DISEASES RESEARCH IN AFRICA

本修订申请旨在建立一个国际 非洲寄生虫病合作研究项目。 的 目的是应用现代生物医学和流行病学工具， 血吸虫病宿主-寄生虫关系的具体方面， 班氏丝虫病和包虫病。 建议的相互依赖 和多学科研究将解决1）具体的决定因素 感染结果的特点和2）利用这种 以利于人类宿主。 一系列领域，人口 建议进行基础和实验室研究。 应用程序 组织了三个项目，处理每种传染病的具体方面， 疾病和两个核心，以协调行政和免疫 这些研究的各个方面。 这些项目的主要目标包括 研究： 项目一： 检测对S.吸虫 感染及其与年龄、感染强度和效果的关系 化疗。 项目二： W的影响。丝虫病母亲的班氏感染 后代免疫病理学 项目三： 确定免疫系统疾病的自然史和免疫谱 对确定的天然和重组寄生虫抗原的应答， 包虫病 该计划是长期合作努力的自然结果 美国-和肯尼亚的调查人员。 它将提供 制定控制策略所需的信息， 培训和技术转让的机会。

This revised application aims at establishing an international collaborative research program on Parasitic Diseases in Africa. The objective is to apply modern biomedical and epidemiological tools to study specific aspects of host-parasite relationship in schistosomiasis, bancroftian filariasis and echinococcosis. The proposed interdependent and multidisciplinary studies will address 1) the determinants of specific features of the outcome of infection and 2) the utilizations of this understanding to favor the human host. A series of field, population based and laboratory investigations are proposed. The application is organized in three projects addressing specific aspects of each infectious disease and two cores to coordinate the administrative and immunological aspects of these studies. The major objectives of these projects include studies of: Project 1: Examination of the immune response to S. haematobium infection and its relationship to age, intensity of infection and effect of chemotherapy. Project 2: Effect of W. bancrofti infection in mothers on filariasis immunopathology in offspring. Project 3: Determine the natural history and spectrum of immunologic responses to defined native and recombinant parasite antigens in echinococcosis. The program is a natural outcome of long standing collaborative efforts between U.S.-based and Kenyan-based investigators. It will provide information necessary to shape control strategies and further opportunities for training and technology transfer.