CORE--BIOMETRY CORE

生物统计核心有两个紧密耦合的主成分， 研究资料库管理组及生物统计组。 的 研究资料库管理组将服务于中心的“核心” 数据库和几乎所有的个别项目，提供 协助设计有效的数据 收集工具和协议;设计、实施和 操作有效的数据库管理系统， 研究数据，包括误差的有效子系统 检测/纠正、数据存储、数据质量保证、安全性 （防止数据丢失或损坏），保护 机密性、数据检索、生成例行报告， 生成专题报告，生成“分析文件”：文件 直接用于统计分析软件。 的 生物统计科将为中心的项目提供协助 在研究设计（临床、流行病学和实验室）中， 协助编写研究方案，协助 监查研究执行和数据收集，以及协作 统计分析和撰写研究报告和论文。 生物统计学核心（包括两个部分）已在 博士赫尔姆斯的指导（作为一个CSCOR项目的组成部分，不相关 镰状细胞中心）10多年。 斯图尔特博士和 伯奇纳尔是9年和5年的核心参与者， 分别 核心是一个运转良好的单元- 开发的操作程序和高效率的计算机 设施

The Biometry Core has two closely coupled principal components, the Research Database Management Section and the Biostatistics Section. The Research Database Management Section will serve the Center's "core" database and almost all of the individual projects, providing the following types of services: assistance in the design of effective data collection instruments and protocols; design, implementation, and operation of efficient database management systems for processing research data, including effective subsystems for error detection/correction, data storage, data quality assurance, security (protection against data loss or corruption), protection of confidentiality, data retrieval, generation of routine reports, generation of special reports, and generation of "analysis files": files structured for direct use by statistical analysis software. The Biostatistics Section will provide the Center's projects with assistance in the design of studies (clinical, epidemiological, and laboratory), assistance in the preparation of research protocols, assistance in monitoring study execution and data collection, and collaboration statistical analyses and writing research reports and papers. The Biometry Core (including both sections) has been in operation under Dr. Helms' direction (as a component of a UNC SCOR project, not related to the Sickle Cell Center) for more than 10 years. Drs. Stewart and Burchinal have been full Core participants for 9 and 5 years, respectively. The core is a smoothly functioning unit with well- developed operational procedures and highly productive computer facilities.