CORE--PATIENT SERVICES

核心——患者服务

• 批准号: 6241645
• 负责人: William C. Mentzer
• 金额: $ 26.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6241645
• 关键词: analgesics; angiography; biomedical facility; blood disorder chemotherapy; bone marrow transplantation; brain metabolism; cerebral ischemia /hypoxia; comprehensive care; human subject; human therapy evaluation; hydroxyurea; interferon gamma; longitudinal human study; magnetic resonance imaging; meperidine; patient care; positron emission tomography; preschool child (1-5); sickle cell anemia; sickle cell crisis; ultrasound blood flow measurement

The Clinical Research and Patient Care Core programs for this center application are based in the East Bay at Children's Hospital-Oakland, Alta Bates Hospital-Berkeley and Highland General Hospital-Oakland and in the West Bay at San Francisco General Hospital/University of California, San Francisco. The large patient population enrolled in these cooperative clinical programs provides us with an ideal resource to conduct the clinical and basic research projects and plan new research projects. The success of these interactions is reflected in our publications related to basic and clinical research on sickle cell disease, (listed in the summary progress report), in our participation in national efforts to establish treatment guidelines for patients with sickle cell disease and in our contributions to implement newborn screening for sickle cell disease. This application describes a number of new clinical research projects: 1) Acute Chest Syndrome, 2) Pediatric Hydroxyurea Trial, 3) Bone Marrow Transplantation, 4) Gamma Interferon- Pneumococcal Vaccine Trial, 5) Longitudinal studies of children up to three years of age and 6) the efficacy of Ketorolac to control pain in patients with vaso-occlusive crises. In addition to the above projects the core will provide necessary blood samples for many basic research programs. In summary, the strength of the clinical core in our Center application will enable us to complete successfully the proposed clinical research projects and participate in the basic research projects.

该中心的临床研究和患者护理核心项目 应用程序是基于东湾在儿童医院奥克兰， 阿尔塔贝茨医院-伯克利和高地总医院-奥克兰和 在旧金山弗朗西斯科总医院/大学的西湾 加州，旧金山弗朗西斯科。 入组的大量患者人群 这些临床合作项目为我们提供了理想的资源， 开展临床和基础研究项目，规划新的研究 项目 这些互动的成功反映在我们的 镰状细胞基础和临床研究相关出版物 疾病，（列在总结进展报告中），在我们的参与中 在国家努力建立治疗指南， 镰状细胞病和我们对执行新生儿 筛查镰状细胞病 本申请描述了一个数字 新的临床研究项目：1）急性胸部综合征，2）儿科 羟基脲试验，3）骨髓移植，4）γ干扰素- 肺炎球菌疫苗试验，5）儿童的纵向研究， 3岁和6）酮咯酸控制疼痛的疗效 血管闭塞危象患者。 除上述项目外， 核心将为许多基础研究提供必要的血液样本 程序. 总之，我们中心的临床核心力量 申请将使我们能够成功地完成拟议的临床 研究项目，并参与基础研究项目。