CORE--PATIENT SERVICES

该中心的临床研究和患者护理核心计划 申请总部设在东湾的奥克兰儿童医院， 阿尔塔·贝茨医院-伯克利和高地综合医院-奥克兰和 在旧金山总医院/华盛顿大学的西湾 加利福尼亚州，旧金山。登记的大量患者群体 这些合作的临床项目为我们提供了理想的资源 实施临床和基础研究项目并计划新的研究 项目。这些互动的成功体现在我们的 与镰状细胞基础和临床研究相关的出版物 疾病(列在简要进度报告中)，在我们的参与中 在国家努力为患有慢性阻塞性肺病患者制定治疗指南 镰状细胞病和我们在实施新生儿方面的贡献 筛查镰状细胞病。这个应用程序描述了一个数字 新的临床研究项目：1)急性胸部综合征，2)儿科 羟基脲试验，3)骨髓移植，4)干扰素- 肺炎球菌疫苗试验，5)对以下儿童的纵向研究 3岁和6岁以下儿童使用酮咯酸控制疼痛的效果 有血管闭塞危象的患者。除上述项目外， 该核心将为许多基础研究提供必要的血液样本 程序。综上所述，我们中心临床核心的实力 应用程序将使我们能够成功完成拟议的临床 研究项目，参与基础研究项目。

The Clinical Research and Patient Care Core programs for this center application are based in the East Bay at Children's Hospital-Oakland, Alta Bates Hospital-Berkeley and Highland General Hospital-Oakland and in the West Bay at San Francisco General Hospital/University of California, San Francisco. The large patient population enrolled in these cooperative clinical programs provides us with an ideal resource to conduct the clinical and basic research projects and plan new research projects. The success of these interactions is reflected in our publications related to basic and clinical research on sickle cell disease, (listed in the summary progress report), in our participation in national efforts to establish treatment guidelines for patients with sickle cell disease and in our contributions to implement newborn screening for sickle cell disease. This application describes a number of new clinical research projects: 1) Acute Chest Syndrome, 2) Pediatric Hydroxyurea Trial, 3) Bone Marrow Transplantation, 4) Gamma Interferon- Pneumococcal Vaccine Trial, 5) Longitudinal studies of children up to three years of age and 6) the efficacy of Ketorolac to control pain in patients with vaso-occlusive crises. In addition to the above projects the core will provide necessary blood samples for many basic research programs. In summary, the strength of the clinical core in our Center application will enable us to complete successfully the proposed clinical research projects and participate in the basic research projects.