CORE--TRANSFECTION VECTOR

向量核心将支持这个项目中的所有单独项目 申请。载体核心将使高度纯化和良好 为研究人员的项目确定了腺病毒载体的特征。这些 病毒包括bcl-xs腺病毒、HRK腺病毒和MBM-2 腺病毒。这些病毒将用于基础研究，以分析 癌细胞中的程序化细胞死亡途径是由 乳腺、卵巢、膀胱和造血细胞。这些病毒 也将在动物模型中使用，以测试这些 病毒作为基因治疗剂。最后，bcl-xs腺病毒将被 由该载体核心产生，用于乳腺癌和 卵巢癌。

The vector core will support all of the individual projects in this application. The vector core will make highly purified and well characterized adenovirus vectors for the investigator's projects. These viruses include a bcl-xs adenovirus, a hrk adenovirus, and an mbm-2 adenovirus. These viruses will be used in basic studies to analyze the programmed cell death pathways in cancer cells that arise from the breast, the ovaries, the bladder and hematopoietic cells. These viruses will also be used in animal models to test the potential of these viruses as gene therapy agents. Finally, the bcl-xs adenovirus will be produced by this vector core for clinical trials in breast cancer and ovarian cancer.