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MOLECULAR SYNOVECTOMY BY IN VIVO GENE TRANSFER

MOLECULAR SYNOVECTOMY BY IN VIVO GENE TRANSFER
通过体内基因转移进行分子滑膜切除术
批准号：
6274760
负责人：
BLAKE J ROESSLER
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274760
关键词：
articular cartilage clinical research clinical trial phase I dosage ganciclovir gene therapy human subject human therapy evaluation immunopathology therapy orthopedics plasmids recombinant DNA rheumatoid arthritis transfection

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英文摘要
We propose a phase-I dose-escalation study of intra-articular pNGVL-TK plasmic DNA followed by systemic ganciclovir (hereafter referred to as TK/GCV) for treatment of active rheumatoid synovitis of the knee. We propose to study 4 doses of pNGVL-TK plasmid DNA over a range of one and on-half logs (0.3 mg, 1.0 mg, 3.3 mg, 10.0 mg). A constant dose of intravenous ganciclovir (5 mg/kg twice daily for 3 days) will be used for each dose of pNGVL-TK plasmid DNA tested. We propose to study 2 patients at each dose of pNGVL-TK plasmic DNA, a total of 8 patients.
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