CORE--RADIATION FACILITY

辐射核心将提供辐射， 项目中的项目。这个核心位于伦巴第 癌症中心，目前包括一个J.L谢泼德马克一，模型 30，铯辐射器。这款Mark I是专门为 实验性的伽马射线它含有2,200个Ci 137 Cs 源头 通过将组织培养瓶堆叠在 旋转平台。一种特殊的旋转管保持器可以 可容纳容量高达50 ml的试管。饼形 旋转鼠标保持器允许同时进行全身照射 一次能杀死十几只老鼠铯辐照器适用于 该计划所需的大部分辐射;然而， 由于无法有效地聚焦和阻挡光束， 将仪器用于局部身体照射，如肿瘤 照射小鼠的腹部。此外， 辐射不能被控制，因为光子能量不能被 调制的基于这些原因，我们要求购买 低成本、便携式X光机，不能专用于 方案的实验工作。要求的X光机是 RS 2000，由Microfocus的Rad-Source部门制造 Imaging，Inc of旋转，IL.蒂莫西·乔根森博士是 辐射核心他的职责包括培训人员 正确和安全地使用仪器，并确保 符合NRC法规。乔根森博士主持了一个内部 咨询委员会。委员会根据需要开会制定规则， 从工具使用的政策，并作出决定， 维护和维修。委员会保证公平公正 调查人员使用这些工具。

The Radiation Core will provide the irradiation in support of all of the projects in the program. This core is housed in the Lombardi Cancer Center and currently consists of a J.L Shepard Mark I, Model 30, Cesium Irradiator. This Mark I is specifically designed for experimental gamma-irradiations. It contains a 2,200 Ci 137 Cs source. Tissue culture flasks are irradiated by stacking them on the rotating platform. A special rotating tube holder can accommodate test tubes with volumes up to 50 ml. A pie-shaped rotating mouse holder allows simultaneous whole-body irradiations of a dozen mice at a time. The cesium irradiator is suitable for the majority of the irradiations required by this program; however, the inability to effectively focus and block the beam makes it difficult to use the instrument for partial body irradiations, such as tumor irradiations in the flanks of mice. Also, the penetrability of the radiation cannot be controlled because the photon energy cannot be modulated. For these reasons, we are requesting the purchase of a low cost, portable, x-ray machine, that cannot be dedicated to the experimental work of the program. The requested x-ray machine is the RS2000, manufactured by Rad-Source, a division of Microfocus Imaging, Inc of Wheeling, IL. Dr. Timothy Jorgenson is Director of the Radiation Core. His responsibilities include training personnel in the proper and safe use of the instruments, and ensuring compliance with NRC regulations. Dr. Jorgenson chairs an Internal Advisory Committee. The Committee meets as needed to set rules and policies from instrument use, and to make decisions concerning maintenance and repairs. The committee guarantees fair and equitable use of the instruments among the investigators.