DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK

描述（由申请人提供）：对潜在基因-环境相互作用的研究可能会提高我们对乳腺癌病因学的理解。本研究的目的是研究DNA修复基因多态性与乳腺癌风险之间的关系。在这个提议中，我们假设DNA修复途径在预防乳腺癌发生中起着重要作用，DNA修复基因的多态性，如XPD，可能会影响乳腺癌的易感性一般，并可能电离辐射诱导的致癌作用，特别是。申请人提出通过设计和分析一项在社区队列中进行的DNA修复基因多态性与乳腺癌发病率之间关联的巢式易控研究来探索这一假设。由于正在进行补充研究，申请方还将能够将巢式病例对照结果与人群子集的队列分析进行比较。这项研究的结果将有助于了解与乳腺癌发生相关的潜在遗传易感因素，并确定可能受益于有针对性干预措施的乳腺癌风险增加的女性。

DESCRIPTION (provided by applicant): Investigations of potential gene-environment interactions may improve our understanding of the etiology of breast cancer. The objectives of this proposal are to examine the association between DNA repair gene polymorphisms and breast cancer risk. In this proposal, we hypothesize that DNA repair pathways play an important role in protecting against breast carcinogenesis, and that polymorphisms in DNA repair genes, such as XPD, may influence breast cancer susceptibility in general, and possibly ionizing radiation-induced carcinogenesis, in particular. The applicant proposes to explore this hypothesis by designing and analyzing a nested ease-control study of the association between DNA repair gene polymorphisms and breast cancer incidence in a community-based cohort. Because of a complementary ongoing study, the applicant will also be able to compare the nested case-control results to a cohort analysis available for a subset of the population. The findings from this study will aid in understanding potential genetic susceptibility factors related to breast carcinogenesis, and in identifying women at increased breast cancer risk who may benefit from targeted interventions.