MEMORY FUNCTION IN ALCOHOLISM--PROCESSES & BRAIN SYSTEM

描述：（改编自研究者摘要）预充是指 事实上，仅仅处理一个项目就可以促进随后的 处理同一个项目。启动效应可以在缺乏 有意识地回忆起先前的研究事件，因此， 提示启动和外显记忆障碍患者 这对这一假设至关重要，因为如果有可能将 外显记忆崩溃与不同脑区损伤启动 这将加强独立记忆系统假说。 记忆障碍者启动效应的评价困难 主题包括启动措施可能不如外显敏感， 记忆措施，并在给定的任务中获得的启动是相关的 基线性能，基线性能较差导致 更大的启动。因此，它的病人甚至有轻微的信息 处理缺陷，这可能造成启动障碍。拟议 该项目将在正常受试者和酗酒者中调查这些问题 患者有不同程度的记忆和处理缺陷。的 拟议的项目将调查这些问题在正常的科目， 酒精中毒患者有不同程度的记忆和处理缺陷。 拟议的实验旨在操纵基线性能 启动措施的水平和敏感性。启动措施， 基线性能和外显记忆将被获得。受试者 将是正常对照组和慢性酒精中毒患者， 他们的外显记忆缺陷的严重程度，从非健忘症 患者没有明显的记忆障碍，通过“边界” 只有轻度记忆缺陷到严重健忘症的“科萨科夫”患者 Korasoff综合征患者。具体而言， 将从MRI获得脑结构。这些措施将与 行为指数，使用多元回归方法， 确定每个大脑区域在感知中的具体作用。词汇 加工、外显记忆和启动量。

DESCRIPTION: (Adapted from the Investigator's Abstract) Priming refers to the fact that the mere processing of an item can facilitate subsequent processing of that same item. Priming effects can occur in the absence of conscious recollection of the prior study episode, and it has, therefore, been suggested that priming and explicit memory disorder patients is critical for this hypothesis, since if it is possible to link the breakdown of explicit memory and priming to damage to different brain regions this would strengthen the independent memory systems hypothesis. Difficulties associated with evaluating priming effects in memory impaired subjects include that priming measures may be less sensitive than explicit memory measures, and that the priming obtained in a given task is related to baseline performance, with poorer baseline performance resulting in greater priming. Therefore, it patients have even mild information processing deficits this may make priming impairments. The proposed project will investigate these issues in normal subjects and alcoholic patients with varying degrees of memory and processing deficits. The proposed project will investigate these issues in normal subjects and alcoholic patients with varying degrees of memory and processing deficits. The proposed experiments are designed to manipulate baseline performance level and sensitivity of the priming measures. Measures of priming, baseline performance, and explicit memory will be obtained. The subjects will be normal controls and chronic alcoholic patients who differ in the severity of their explicit memory defects, ranging from non amnesic patients without noticeable memory impairments through "borderline Korsakoff" patients with only mild memory deficits to severely amnesic patients with Korasoff's syndrome. Measures of volume loss in specific brain structures will be obtained from MRI. These measures will be related to the behavioral indices, using a multiple regression approach, to determine the specific role of each brain region in perceptual. lexical processing, explicit memory and magnitude of priming.