MEMORY FUNCTION IN ALCOHOLISM--PROCESSES & BRAIN SYSTEM

描述：(改编自《调查员摘要》)引爆是指 事实上，仅仅是对物品的处理就可以促进后续 处理相同的项目。启动效果可能发生在没有 对先前研究情节的有意识的回忆，因此， 有人认为启动和外显记忆障碍患者 对这一假设至关重要，因为如果有可能将 外显记忆崩溃与启动对不同脑组织的损伤 这将强化独立记忆系统假说。 与评估记忆受损的启动效应相关的困难 主题包括启动措施可能不像显性措施那样敏感 记忆测量，以及在给定任务中获得的启动与 到基线性能，较差的基线性能会导致 更大的引爆力。因此，it患者甚至有轻微的信息。 加工缺陷这可能会造成启动损伤。建议数 Project将在正常受试者和酗酒者中调查这些问题 患者有不同程度的记忆和处理缺陷。这个 拟议的项目将在正常科目中调查这些问题，并 酗酒患者有不同程度的记忆和处理缺陷。 拟议中的实验旨在操纵基线性能 启动措施的水平和敏感性。引爆的措施， 基准性能，并将获得显式内存。主题 将是正常对照组和慢性酒精中毒患者，他们在 他们的外显记忆缺陷的严重程度，从非健忘症 没有明显记忆障碍的患者 Korsakoff“仅有轻度记忆障碍到严重健忘症的患者 科拉索夫综合征患者。单位体积损失的量度 大脑结构将从核磁共振成像中获得。这些措施将是相关的 行为指数，使用多元回归方法，以 确定每个大脑区域在知觉中的具体作用。词汇化 加工、外显记忆和启动大小。

DESCRIPTION: (Adapted from the Investigator's Abstract) Priming refers to the fact that the mere processing of an item can facilitate subsequent processing of that same item. Priming effects can occur in the absence of conscious recollection of the prior study episode, and it has, therefore, been suggested that priming and explicit memory disorder patients is critical for this hypothesis, since if it is possible to link the breakdown of explicit memory and priming to damage to different brain regions this would strengthen the independent memory systems hypothesis. Difficulties associated with evaluating priming effects in memory impaired subjects include that priming measures may be less sensitive than explicit memory measures, and that the priming obtained in a given task is related to baseline performance, with poorer baseline performance resulting in greater priming. Therefore, it patients have even mild information processing deficits this may make priming impairments. The proposed project will investigate these issues in normal subjects and alcoholic patients with varying degrees of memory and processing deficits. The proposed project will investigate these issues in normal subjects and alcoholic patients with varying degrees of memory and processing deficits. The proposed experiments are designed to manipulate baseline performance level and sensitivity of the priming measures. Measures of priming, baseline performance, and explicit memory will be obtained. The subjects will be normal controls and chronic alcoholic patients who differ in the severity of their explicit memory defects, ranging from non amnesic patients without noticeable memory impairments through "borderline Korsakoff" patients with only mild memory deficits to severely amnesic patients with Korasoff's syndrome. Measures of volume loss in specific brain structures will be obtained from MRI. These measures will be related to the behavioral indices, using a multiple regression approach, to determine the specific role of each brain region in perceptual. lexical processing, explicit memory and magnitude of priming.