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SCOR IN PEDIATRIC CARDIOVASCULAR DISEASE

小儿心血管疾病中的 SCOR

基本信息

批准号：
2638015
负责人：
Bradley Barth Keller
金额：
$ 135.9万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-01-01 至 1999-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2638015
关键词：
biomechanics congenital cardiovascular disorder pediatrics

项目摘要

This SCOR proposal for a Pediatric Cardiovascular Disease Center is a series of fundamental studies aimed at understanding the biomechanical aspects of cardiac development to normal cardiovascular development and human congenital cardiac defects. The heart is the first functioning organ in the embryo. The embryonic heart is transformed by genetic and epigenetic factors from a tube to a four chambered heart. Errors in this development process produce a wide spectrum of congenital heart defects. Rapid advances in molecular and cellular biology are identifying genetic pathways integral to development. Less is known, however, about the mechanical forces that drive morphogenesis and growth from uncoiling of the DNA strand prior to transcription to the cardiac pumping cycle. Thus, the biomechanical forces at all levels of the developing heart have a central role in formation of the heart and circulation. The long term aid of this SCOR Project is to define supports sophisticated analytic techniques in three cores: Bioengineering, Cardiovascular Physiology and Morphometry to understand mechanisms that interrelate function and form during normal and abnormal cardiovascular morphogenesis. Four projects apply the multidisciplinary expertise available in each core to study: 1. The heart rate and blood flow velocity variability in the human from 10 to 18 weeks gestation. 2. Ventricular/vascular coupling during cardiovascular development. 3. Biomechanical modeling of growth and morphogenesis of the embryonic hear. 4. Atrial/ventricular coupling during cardiovascular development. These studies are fundamental to understanding the biomechanical environment of the developing heart and circulation and provide important information on pathogenetic mechanisms of congenital and acquired cardiovascular disease in humans.

SCOR 针对儿科心血管疾病中心的提案是旨在了解生物力学的一系列基础研究心脏发育到正常心血管发育的各个方面人类先天性心脏缺陷。心脏是最先发挥作用的胚胎中的器官。胚胎心脏是通过遗传和从管道到四室心脏的表观遗传因素。这方面的错误发育过程会产生多种先天性心脏病。分子和细胞生物学的快速发展正在识别遗传发展不可或缺的途径。然而，关于驱动形态发生和展开生长的机械力转录进入心脏泵血周期之前的DNA链。因此，发育中的心脏各个层面的生物力学力在心脏的形成和循环中起着核心作用。长期来看该 SCOR 项目的帮助是定义支持复杂的分析三个核心技术：生物工程、心血管生理学和形态测量学以了解功能和形式相互关联的机制在正常和异常的心血管形态发生期间。四个项目应用每个核心中可用的多学科专业知识来研究： 1. 人体心率和血流速度的变异性妊娠10至18周。 2.心血管发育过程中的心室/血管耦合。 3. 胚胎生长和形态发生的生物力学模型听到。 4.心血管发育过程中的心房/心室耦合。这些研究对于理解生物力学至关重要心脏和循环发育的环境，并提供重要的先天性和后天性的发病机制信息人类心血管疾病。