CORE--MOUSE MUTAGENESIS FACILITY

核心——小鼠诱变设施

• 批准号: 6203492
• 负责人: DAVID WARSHAWSKY
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203492
• 关键词: animal care; animal colony; biomedical facility; carcinogen testing; computer data analysis; laboratory mouse; mutagen testing; mutagens; veterinary medicine

The purpose of the mutagenesis core is to provide assistance to each of the research projects in the administration of mutagens and the subsequent follow-up and observation of the animals until they are assayed. The mutagens to be used in commin are ENU and 4-aminobiphenyl. DMBA will be used by Drs. Tishfield and Doetschman, and ionizing radiation by Drs. Stringer and Tishfield. The Cobalt-60 source, however, is not part of the mutagenesis core, but is available through Dr. Denman, a radiation biologist, in Radiology (see attached letter). The core also will provide adduct analysis, particularly for Dr. Doetschman's project.

诱变核心的目的是为每一个突变体提供帮助。 在诱变剂管理和随后的研究项目 对动物进行跟踪和观察，直至进行测定。 的 通常使用的诱变剂是ENU和4-氨基联苯。 DMBA将是 Tishfield博士和Doetschman博士使用的电离辐射， 斯特林格和蒂什菲尔德。 然而，钴-60源不是 诱变核心，但可通过登曼博士，辐射 生物学家，放射学（见随附信函）。 核心还将提供 加合物分析特别是多奇曼博士的项目