CORE--MOUSE MUTAGENESIS FACILITY

核心——小鼠诱变设施

• 批准号: 6106290
• 负责人: DAVID WARSHAWSKY
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6106290
• 关键词: animal care; animal colony; biomedical facility; carcinogen testing; computer data analysis; laboratory mouse; mutagen testing; mutagens; veterinary medicine

The purpose of the mutagenesis core is to provide assistance to each of the research projects in the administration of mutagens and the subsequent follow-up and observation of the animals until they are assayed. The mutagens to be used in commin are ENU and 4-aminobiphenyl. DMBA will be used by Drs. Tishfield and Doetschman, and ionizing radiation by Drs. Stringer and Tishfield. The Cobalt-60 source, however, is not part of the mutagenesis core, but is available through Dr. Denman, a radiation biologist, in Radiology (see attached letter). The core also will provide adduct analysis, particularly for Dr. Doetschman's project.

突变核心的目的是为每个 诱变剂管理方面的研究项目及其后续 对动物进行跟踪观察，直至化验完毕。这个 在COMIN中使用的诱变剂是ENU和4-氨基联苯。DMBA将是 Tishfield和Doetschman博士使用的是电离辐射，Detschman博士使用的是电离辐射。 斯特林格和蒂什菲尔德。然而，钴-60源并不是 诱变核心，但可通过Denman博士进行辐射 生物学家，放射学(见附函)。核心还将提供 引用分析，特别是对Doetschman博士的项目。