MECHANISMS OF CHEMICAL MUTAGENESIS AND REPAIR OF DNA ADDUCTS
DNA加合物的化学诱变和修复机制
基本信息
- 批准号:6106124
- 负责人:
- 金额:$ 19.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-03-01 至 2000-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The long-range goals of this research are two-fold; to establish the
mutagenic potential of selected environmental mutagens and to explore the
molecular basis for recognition and repaired of damaged DNA.
Excellent progress has been made during the past project period.
Quantitative methods have been developed that allowed us to establish in
vitro and in vivo the mutagenic profiles of defined DNA adducts.
Fundamental principles have emerged that will facilitate analyses of
mutational spectra produced by environmental mutagens. For example, using
site-specific techniques, we can predict nucleotide sequence contexts of
mutational hot spots. We also discovered that DNA polymerases differ
strikingly from one another in their miscoding potential with respect to
certain DNA adducts. We also describe a new pathway for repair of
oxidative DNA damage in E. coli.
In the next project period, we will seek to determine the mutagenic
potential in vitro and in vivo for PhIP and 8-aminoguanine, a modified
DNA base which accumulates in the liver of animals treated with 2-
nitropropane. We will use our experimental systems to explore molecular
mechanisms of base substitutions and deletion mutagenesis for abasic
sites, aminofluorene adducts and four stereoisomers derived from
benzo(a)pyrene. Part of this project is devoted to studies of DNA repair
enzymes; we propose to isolate and purify homologs of Fpg protein and
MutY protein from mammalian sources. Finally, we will study the
interaction of a single zinc finger derived from Fpg protein with damaged
DNA.
这项研究的长期目标是双重的;建立
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SHINYA SHIBUTANI其他文献
SHINYA SHIBUTANI的其他文献
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{{ truncateString('SHINYA SHIBUTANI', 18)}}的其他基金
Genotoxicity of Estrogen Compounds in Endocrine Therapy
内分泌治疗中雌激素化合物的遗传毒性
- 批准号:
7106592 - 财政年份:2005
- 资助金额:
$ 19.84万 - 项目类别:
Genotoxicity of Estrogen Compounds in Endocrine Therapy
内分泌治疗中雌激素化合物的遗传毒性
- 批准号:
7409606 - 财政年份:2005
- 资助金额:
$ 19.84万 - 项目类别:
Genotoxicity of Estrogen Compounds in Endocrine Therapy
内分泌治疗中雌激素化合物的遗传毒性
- 批准号:
7232070 - 财政年份:2005
- 资助金额:
$ 19.84万 - 项目类别:
Genotoxicity of Estrogen Compounds in Endocrine Therapy
内分泌治疗中雌激素化合物的遗传毒性
- 批准号:
6917467 - 财政年份:2005
- 资助金额:
$ 19.84万 - 项目类别:
Genotoxicity of Estrogen Compounds in Endocrine Therapy
内分泌治疗中雌激素化合物的遗传毒性
- 批准号:
7618442 - 财政年份:2005
- 资助金额:
$ 19.84万 - 项目类别:
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