CENTER FOR REPRODUCTIVE SCIENCES

堪萨斯大学生殖与发育生物学家 医学中心建议成立专注于主题的基础研究P30中心 与生育和不孕有关。该中心将由保罗指导 F·特拉诺娃，生理学和妇产科教授，以及 副主任将由杰出教授吉尔伯特·S·格林沃尔德担任 生理学博士。主要研究人员及其研究兴趣 是：Glen Andrews，Structure/Regular of the Metals thionein gene和 细胞因子/生长因子在植入前的转录调控 胚胎发育；S.K.Dey，生长因子的表达和调节 在围着床期的子宫和胚胎中；乔治 Enders，精子发生过程中的细胞相互作用包括 生精细胞表面细胞黏附分子的鉴定 亨特，母体细胞与胚胎外细胞的免疫相互作用 促进生育；Imakawa和彦，蛋白质鉴定 参与孕妇对怀孕的认可；威廉·金赛，Signal 受精时的转导事件与非 受体酪氨酸蛋白激酶；Girish Shah，细胞和分子 催乳素基因的神经内分泌调节机制 表达和催乳素分泌；迈克尔·苏亚雷斯，滋养层细胞的控制 新的催乳素样蛋白的分化和鉴定 由胎盘细胞表达；约瑟夫·塔什，基本生化机制 以蛋白质为主调节精子鞭毛运动 磷酸化；Paul Terranova，卵巢肿瘤坏死因子的作用- 卵巢细胞生长、分化和发育中的阿尔法 Voogt，催乳素分泌的神经化学调节及其影响 衰老对催乳素和多巴胺分泌的影响。核心实验室 和(导演)是：细胞培养核心(琼·亨特)提供高 用于细胞培养和管理常用细胞的高质量/低成本试剂 台词。图像分析/摄影核心(Joseph Tash)提供制作 以及与原位杂交相关的图像分析， 放射自显影，免疫细胞化学和组织学。转基因核心(S.K. Dey)生产转基因动物，并管理各种 转基因株系。迈克尔·沃尔夫的新程序开发项目， 生理学助理教授，题为《转录调控 促性腺激素β亚基在发育过程中和荷尔蒙的作用 包括并将扩展和补充现有的分子研究 生物学。总而言之，这个中心将是一个非常刺激的 促进生殖领域高质量基础研究的环境 科学。

Reproductive and developmental biologists at the University of Kansas Medical Center propose a Basic Research P30 Center that focuses on topics related to fertility and infertility. The Center will be directed by Paul F. Terranova, Professor of Physiology and Obstetrics & Gynecology, and the Associate Director will be Gilbert S. Greenwald, Distinguished Professor of Physiology. The primary investigators and their research interests are: Glen Andrews, structure/regulation of the metallothionein gene and transcriptional control of cytokines/growth factors in preimplantation embryo development; S.K. Dey, expression and regulation of growth factors in the uterus and embryo during the peri-implantation period; George Enders, cellular interactions during spermatogenesis including identification of cell adhesion molecules on spermatogenic cells; Joan Hunt, immunologic interactions between maternal and extraembryonic cells that promote fertility; Kazuhiko Imakawa, identification of proteins involved in the maternal recognition of pregnancy; William Kinsey, signal transduction events at fertilization with specific interest in non- receptor tyrosine protein kinases; Girish Shah, cellular and molecular mechanisms associated with neuroendocrine regulation of prolactin gene expression and prolactin secretion; Michael Soares, control of trophoblast differentiation and identification of novel prolactin-like proteins expressed by placental cells; Joseph Tash, basic biochemical mechanisms regulating sperm flagellar movement with a major emphasis on protein phosphorylation; Paul Terranova, role of ovarian tumor necrosis factor- alpha in growth, differentiation and development of ovarian cells; James Voogt, neurochemical regulation of prolactin secretion and the influence of aging on secretion of prolactin and dopamine. The Core laboratories and (Directors) are: Cell Culture Core (Joan Hunt) provides high quality/low cost reagents for cell culture and manages commonly used cell lines. Image Analysis/Photography Core (Joseph Tash) provides production and analysis of images associated with in situ hybridization, autoradiography, immunocytochemistry and histology. Transgenic Core (S.K. Dey) produces transgenic animals and manages the breeding of various transgenic lines. A New Program Development Project by Michael Wolfe, Assistant Professor of Physiology, entitled "Transcriptional Regulation of Gonadotropin beta Subunits During Development and by Hormones" is also included and will expand and complement existing research in molecular biology. In summary, this center will be an extremely stimulating environment that fosters high quality basic research in the reproductive sciences.