A Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy

项目总结 超过1760万北美人居住在石油和天然气开发设施(OGD)1.6公里范围内。最新研究 表明OGD导致生殖毒物(例如，颗粒物、挥发性有机物质)的释放 化合物[挥发性有机化合物]、多环芳烃[多环芳烃])可能危害人类健康的水平，包括 生育力、早孕丢失、妊娠相关疾病和生育结果。OGD的流行病学研究 到目前为止，主要关注活产结局，还没有包括个人接触测量，以及 关于关键混杂因素的数据很少。基于NIEHS资助的博士前奖学金的数据分析 (F31-ES029801)和她博士后研究中的前瞻性队列设计培训，Mary Willis博士的早期 独立奖申请启动首个与OGD相关的污染和 生殖健康。这项建议利用了正在进行的在线怀孕研究招聘(Presto， R01-HD086742)，这是一项基于互联网的对北美夫妇试图怀孕的先入为主的队列研究 (N&GT；16,000名女性参与者)，以检查与OGD相关的暴露对生殖健康的影响。这 Cohort具有显著的地理多样性，横跨美国所有50个州和加拿大所有10个省。到目前为止， &gt；4500名妇女居住在有OGD活动的社区，该应用程序将使用地理目标方法 再招收1000名女性。AIM 1在Presto队列中开发了与OGD相关的暴露指标，并 这是威利斯博士先前工作的延伸。暴露评估方法包括1)复杂的空间数据 整合可追溯到参与者自己出生的行业相关信息，1b)补充 OGD感知风险问卷，以及1c)个人暴露在空气、水和噪音中的子集 150名妇女在怀孕前至怀孕早期的三个时间点。所有暴露评估 方法是经过验证的、最先进的方法。AIM 2将这些暴露指标应用于纵向 研究OGD对整个孕期重要生殖健康结局影响的框架 一群人。结果包括2a)生育力(受精率、每个周期的怀孕概率)、2b)妊娠损失。 (自然流产)，2c)妊娠相关高血压和代谢紊乱(妊娠期高血压， 先兆子痫、妊娠期糖尿病)和出生结局(早产、低出生体重)。这些目标设定了 探索个人或社区干预措施的有效性的“从研究到行动”提案的阶段 具体的OGD暴露，以及R01提案的基础，以及对产妇产后的跟踪 健康和儿童发展。通过利用已建立的基于互联网的前瞻性队列研究，这 该提案解决了有效评估新出现的健康影响的后勤挑战 环境危害。这一项目的成果具有很大的潜力，可以通过展示 一个新的与政策相关的框架，用于调查新出现的环境危害。这一奖项将允许威利斯博士 在环境流行病学、数据科学和生殖健康的交叉领域开始她的职业生涯。

PROJECT SUMMARY Over 17.6 million North Americans live within 1.6km of an oil and gas development (OGD) facility. Recent studies indicate that OGD results in the release of reproductive toxicants (e.g., particulate matter, volatile organic compounds [VOCs], polycyclic aromatic hydrocarbons [PAHs]) at levels that may harm human health, including fertility, early pregnancy loss, pregnancy-related disorders, and birth outcomes. Epidemiologic studies on OGD to date have largely focused on live birth outcomes, have not included personal exposure measurements, and have little data on key confounders. Building upon data analysis from an NIEHS-funded predoctoral fellowship (F31-ES029801) and training in prospective cohort designs in her postdoctoral research, Dr. Mary Willis’ Early Independence Award application launches the first prospective cohort study on OGD-related pollution and reproductive health. This proposal leverages ongoing recruitment from the Pregnancy Study Online (PRESTO, R01-HD086742), an internet-based preconception cohort study of North American couples trying to conceive (n>16,000 female participants), to examine the influence of OGD-related exposures on reproductive health. This cohort has remarkable geographic diversity, spanning all 50 U.S. states and all 10 Canadian provinces. To date, >4,500 of the women reside in communities with OGD activity and this application will use geo-targeted methods to enroll an additional 1,000 women. Aim 1 develops OGD-related exposure metrics in the PRESTO cohort, an extension of Dr. Willis’ previous work. Exposure assessment methods include 1a) complex spatial data integration of industry-related information that spans back to participants’ own births, 1b) a supplemental questionnaire of perceived risks about OGD, and 1c) personal exposures to air, water, and noise in a subset of 150 women at three time points in the preconception to early pregnancy periods. All exposure assessment methods are validated, state-of-the-art approaches. Aim 2 applies these exposure metrics in a longitudinal framework to examine the influence of OGD on important reproductive health outcomes in the full PRESTO cohort. Outcomes include 2a) fertility (fecundability, the per-cycle probability of pregnancy), 2b) pregnancy loss (spontaneous abortion), 2c) pregnancy-related hypertensive and metabolic disorders (gestational hypertension, pre-eclampsia, gestational diabetes), and 2d) birth outcomes (preterm birth, low birth weight.) The aims set the stage for a “Research to Action” proposal that explores the efficacy of personal or community interventions for specific OGD exposures, as well as the groundwork for an R01 proposal with follow-up for maternal postpartum health and child development. By leveraging an established internet-based prospective cohort study, this proposal addresses the logistical challenges of efficiently assessing the influence of health effects of emerging environmental hazards. The results of this project have high potential to improve public health by demonstrating a novel policy-relevant framework to investigate emerging environmental hazards. This award will allow Dr. Willis to launch her career at the intersection of environmental epidemiology, data science, and reproductive health.