A Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy

关于石油和天然气开发、生育力和怀孕的孕前队列研究

• 批准号: 10705071
• 负责人: Mary D Willis
• 金额: $ 41.25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705071
• 关键词: Address; Affect; Air; American; Aromatic Polycyclic Hydrocarbons; Award; Back; Benzene; Birth; Boston; Canada; Chemicals; Child; Child Development; Child Health; Cohort Studies; Communities; Complex; Conceptions; Contracts; Couples; Data; Data Analyses; Data Collection; Data Science; Development; Diet; Disease; Enrollment; Environmental Epidemiology; Environmental Hazards; Environmental Pollutants; Epidemiology; Exposure to; Faculty; Fellowship; Female; Fertility; Flare; Formaldehyde; Funding; Gases; Geography; Gestational Diabetes; Grant; HRK gene; Health; Human; Hypertension; Industry; Institution; Interdisciplinary Study; Internet; Late pregnancy; Life Style; Light; Live Birth; Low Birth Weight Infant; Measurement; Measures; Medical History; Menstrual cycle; Mentors; Metabolic Diseases; Methods; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Noise; Oils; Outcome; Participant; Particulate Matter; Pharmaceutical Preparations; Play; Policies; Pollution; Positioning Attribute; Postdoctoral Fellow; Postpartum Women; Pre-Eclampsia; Pregnancy; Pregnancy loss; Premature Birth; Probability; Production; Prospective cohort; Prospective, cohort study; Province; Public Health; Public Health Schools; Questionnaires; Recording of previous events; Reporting; Reproductive Health; Research; Research Design; Research Personnel; Resources; Risk; Role; Spontaneous abortion; Surveys; TNFSF15 gene; Techniques; Time; Toluene; Toxicology; Training; United States; United States National Institutes of Health; Universities; Water; Woman; Work; Workplace; career; cohort; community intervention; cost effective; data integration; design; early pregnancy; early pregnancy loss; epidemiology study; follow-up; improved; novel; participant enrollment; pollutant; population health; postpartum health; pre-doctoral; pregnancy hypertension; professor; prospective; recruit; reproductive; risk perception; social stressor; sociodemographics; time-to-pregnancy; toxicant; trying to conceive; volatile organic compound

PROJECT SUMMARY Over 17.6 million North Americans live within 1.6km of an oil and gas development (OGD) facility. Recent studies indicate that OGD results in the release of reproductive toxicants (e.g., particulate matter, volatile organic compounds [VOCs], polycyclic aromatic hydrocarbons [PAHs]) at levels that may harm human health, including fertility, early pregnancy loss, pregnancy-related disorders, and birth outcomes. Epidemiologic studies on OGD to date have largely focused on live birth outcomes, have not included personal exposure measurements, and have little data on key confounders. Building upon data analysis from an NIEHS-funded predoctoral fellowship (F31-ES029801) and training in prospective cohort designs in her postdoctoral research, Dr. Mary Willis’ Early Independence Award application launches the first prospective cohort study on OGD-related pollution and reproductive health. This proposal leverages ongoing recruitment from the Pregnancy Study Online (PRESTO, R01-HD086742), an internet-based preconception cohort study of North American couples trying to conceive (n>16,000 female participants), to examine the influence of OGD-related exposures on reproductive health. This cohort has remarkable geographic diversity, spanning all 50 U.S. states and all 10 Canadian provinces. To date, >4,500 of the women reside in communities with OGD activity and this application will use geo-targeted methods to enroll an additional 1,000 women. Aim 1 develops OGD-related exposure metrics in the PRESTO cohort, an extension of Dr. Willis’ previous work. Exposure assessment methods include 1a) complex spatial data integration of industry-related information that spans back to participants’ own births, 1b) a supplemental questionnaire of perceived risks about OGD, and 1c) personal exposures to air, water, and noise in a subset of 150 women at three time points in the preconception to early pregnancy periods. All exposure assessment methods are validated, state-of-the-art approaches. Aim 2 applies these exposure metrics in a longitudinal framework to examine the influence of OGD on important reproductive health outcomes in the full PRESTO cohort. Outcomes include 2a) fertility (fecundability, the per-cycle probability of pregnancy), 2b) pregnancy loss (spontaneous abortion), 2c) pregnancy-related hypertensive and metabolic disorders (gestational hypertension, pre-eclampsia, gestational diabetes), and 2d) birth outcomes (preterm birth, low birth weight.) The aims set the stage for a “Research to Action” proposal that explores the efficacy of personal or community interventions for specific OGD exposures, as well as the groundwork for an R01 proposal with follow-up for maternal postpartum health and child development. By leveraging an established internet-based prospective cohort study, this proposal addresses the logistical challenges of efficiently assessing the influence of health effects of emerging environmental hazards. The results of this project have high potential to improve public health by demonstrating a novel policy-relevant framework to investigate emerging environmental hazards. This award will allow Dr. Willis to launch her career at the intersection of environmental epidemiology, data science, and reproductive health.

项目摘要 超过1760万北美人居住在石油和天然气开发（OGD）设施的1.6公里范围内。最近的研究 表明OGD导致生殖毒物的释放（例如，颗粒物、挥发性有机物 化合物[挥发性有机化合物]、多环芳烃[多环芳烃]），其含量可能危害人类健康，包括 生育、早孕丢失、妊娠相关疾病和分娩结果。OGD的流行病学研究 到目前为止，主要集中在活产结果，没有包括个人暴露测量， 关于关键混杂因素的数据很少。基于NIEHS资助的博士前奖学金的数据分析 （F31-ES 029801）和前瞻性队列设计培训，在她的博士后研究，博士玛丽威利斯的早期 独立奖申请启动了第一个关于OGD相关污染的前瞻性队列研究， 生殖健康。该提案利用了正在进行的妊娠研究在线（PRESTO， R 01-HD 086742），这是一项基于互联网的针对北美夫妇的孕前队列研究， （n> 16，000名女性参与者），以检查OGD相关暴露对生殖健康的影响。这 这一群体具有显著的地理多样性，横跨美国所有50个州和加拿大所有10个省。到目前为止， 超过4，500名妇女居住在有OGD活动的社区，该应用程序将使用地理定位方法 再招收1,000名女性目的1在PRESTO队列中开发OGD相关暴露指标， 威利斯博士之前工作的延伸暴露评估方法包括1a）复杂的空间数据 1b）一个补充的信息， 关于OGD的感知风险问卷，以及1c）个人暴露于空气，水和噪音的子集， 150名妇女在孕前至早孕期的三个时间点。所有暴露评估 方法是经过验证的，最先进的方法。目标2以纵向方式应用这些暴露度量 在PRESTO全面框架内审查OGD对重要生殖健康结果的影响 队列。结果包括2a）生育力（受精能力，每个周期的怀孕概率），2b）妊娠丢失 （自然流产），2c）妊娠相关的高血压和代谢紊乱（妊娠高血压， 先兆子痫、妊娠糖尿病），和2d）出生结果（早产、低出生体重）。目标设定了 “从研究到行动”提案的阶段，该提案探讨了个人或社区干预措施的有效性， 具体的OGD暴露，以及R 01建议的基础，包括产妇产后随访 健康和儿童发展。通过利用一项基于互联网的前瞻性队列研究， 该提案解决了有效评估新兴疾病对健康影响的后勤挑战， 环境危害该项目的成果具有很大的潜力，通过展示 一个新的政策相关框架，以调查新出现的环境危害。这个奖项将使威利斯博士 在环境流行病学，数据科学和生殖健康的交叉点开始她的职业生涯。

项目成果

It's electric! An environmental equity perspective on the lifecycle of our energy sources.

• DOI: 10.1097/ee9.0000000000000246
• 发表时间: 2023-04
• 期刊: ENVIRONMENTAL EPIDEMIOLOGY
• 影响因子: 3.6
• 作者: Willis, Mary D.;Cushing, Lara J.;Buonocore, Jonathan J.;Deziel, Nicole C.;Casey, Joan A.
• 通讯作者: Casey, Joan A.