Development of Innovative Foldamers for the Peptide Receptor Radionuclide Therapy of Tumours Overexpressing Cholecystokinin-2 Receptors

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Peptide Receptor Radionuclide Therapy (PRRT) is a systematic treatment used to deliver high levels of radiation to cancer using radiopharmaceuticals known as theranostic agents (TAs). Until now TAs have been limited to only a few cancer types. This project aims to develop TAs to treat cancers which overexpress an important molecular target known as Cholecystokinin-2 (CCK-2) receptors. These TAs will be prepared in an innovative manner to display high affinity and stability for CCK-2 receptors.